TY - JOUR
T1 - Network homogeneity reveals decreased integrity of default-mode network in ADHD
AU - Uddin, Lucina Q.
AU - Kelly, A. M.Clare
AU - Biswal, Bharat B.
AU - Margulies, Daniel S.
AU - Shehzad, Zarrar
AU - Shaw, David
AU - Ghaffari, Manely
AU - Rotrosen, John
AU - Adler, Lenard A.
AU - Castellanos, F. Xavier
AU - Milham, Michael P.
N1 - Funding Information:
The authors would like to thank Dr. Andrew Kirsch for conducting clinical assessments. This work was supported by grants provided to FXC by the Stavros S. Niarchos Foundation, NIMH (5R21MH066393 and 5T32MH067763), and the Leon Lowenstein Foundation.
PY - 2008/3/30
Y1 - 2008/3/30
N2 - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
AB - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
KW - Attention
KW - Attention-deficit/hyperactivity disorder
KW - Functional connectivity
KW - Posterior cingulate
KW - Precuneus
KW - Resting state networks
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=39749202359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749202359&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2007.11.031
DO - 10.1016/j.jneumeth.2007.11.031
M3 - Article
C2 - 18190970
AN - SCOPUS:39749202359
VL - 169
SP - 249
EP - 254
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
IS - 1
ER -