Network homogeneity reveals decreased integrity of default-mode network in ADHD

Lucina Q Uddin, A. M Clare Kelly, Bharat B. Biswal, Daniel S. Margulies, Zarrar Shehzad, David Shaw, Manely Ghaffari, John Rotrosen, Lenard A. Adler, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournal of Neuroscience Methods
Volume169
Issue number1
DOIs
StatePublished - Mar 30 2008
Externally publishedYes

Fingerprint

Parietal Lobe
Seeds
Magnetic Resonance Imaging
Brain
Population
Neuropathology

Keywords

  • Attention
  • Attention-deficit/hyperactivity disorder
  • fMRI
  • Functional connectivity
  • Posterior cingulate
  • Precuneus
  • Resting state networks

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Uddin, L. Q., Kelly, A. M. C., Biswal, B. B., Margulies, D. S., Shehzad, Z., Shaw, D., ... Milham, M. P. (2008). Network homogeneity reveals decreased integrity of default-mode network in ADHD. Journal of Neuroscience Methods, 169(1), 249-254. https://doi.org/10.1016/j.jneumeth.2007.11.031

Network homogeneity reveals decreased integrity of default-mode network in ADHD. / Uddin, Lucina Q; Kelly, A. M Clare; Biswal, Bharat B.; Margulies, Daniel S.; Shehzad, Zarrar; Shaw, David; Ghaffari, Manely; Rotrosen, John; Adler, Lenard A.; Castellanos, F. Xavier; Milham, Michael P.

In: Journal of Neuroscience Methods, Vol. 169, No. 1, 30.03.2008, p. 249-254.

Research output: Contribution to journalArticle

Uddin, LQ, Kelly, AMC, Biswal, BB, Margulies, DS, Shehzad, Z, Shaw, D, Ghaffari, M, Rotrosen, J, Adler, LA, Castellanos, FX & Milham, MP 2008, 'Network homogeneity reveals decreased integrity of default-mode network in ADHD', Journal of Neuroscience Methods, vol. 169, no. 1, pp. 249-254. https://doi.org/10.1016/j.jneumeth.2007.11.031
Uddin, Lucina Q ; Kelly, A. M Clare ; Biswal, Bharat B. ; Margulies, Daniel S. ; Shehzad, Zarrar ; Shaw, David ; Ghaffari, Manely ; Rotrosen, John ; Adler, Lenard A. ; Castellanos, F. Xavier ; Milham, Michael P. / Network homogeneity reveals decreased integrity of default-mode network in ADHD. In: Journal of Neuroscience Methods. 2008 ; Vol. 169, No. 1. pp. 249-254.
@article{49e55466ce0849c49ee8422e4aa42b97,
title = "Network homogeneity reveals decreased integrity of default-mode network in ADHD",
abstract = "Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, {"}network homogeneity{"}, that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.",
keywords = "Attention, Attention-deficit/hyperactivity disorder, fMRI, Functional connectivity, Posterior cingulate, Precuneus, Resting state networks",
author = "Uddin, {Lucina Q} and Kelly, {A. M Clare} and Biswal, {Bharat B.} and Margulies, {Daniel S.} and Zarrar Shehzad and David Shaw and Manely Ghaffari and John Rotrosen and Adler, {Lenard A.} and Castellanos, {F. Xavier} and Milham, {Michael P.}",
year = "2008",
month = "3",
day = "30",
doi = "10.1016/j.jneumeth.2007.11.031",
language = "English (US)",
volume = "169",
pages = "249--254",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Network homogeneity reveals decreased integrity of default-mode network in ADHD

AU - Uddin, Lucina Q

AU - Kelly, A. M Clare

AU - Biswal, Bharat B.

AU - Margulies, Daniel S.

AU - Shehzad, Zarrar

AU - Shaw, David

AU - Ghaffari, Manely

AU - Rotrosen, John

AU - Adler, Lenard A.

AU - Castellanos, F. Xavier

AU - Milham, Michael P.

PY - 2008/3/30

Y1 - 2008/3/30

N2 - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.

AB - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.

KW - Attention

KW - Attention-deficit/hyperactivity disorder

KW - fMRI

KW - Functional connectivity

KW - Posterior cingulate

KW - Precuneus

KW - Resting state networks

UR - http://www.scopus.com/inward/record.url?scp=39749202359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749202359&partnerID=8YFLogxK

U2 - 10.1016/j.jneumeth.2007.11.031

DO - 10.1016/j.jneumeth.2007.11.031

M3 - Article

C2 - 18190970

AN - SCOPUS:39749202359

VL - 169

SP - 249

EP - 254

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

IS - 1

ER -