Abstract
Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-254 |
| Number of pages | 6 |
| Journal | Journal of Neuroscience Methods |
| Volume | 169 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 30 2008 |
| Externally published | Yes |
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Keywords
- Attention
- Attention-deficit/hyperactivity disorder
- fMRI
- Functional connectivity
- Posterior cingulate
- Precuneus
- Resting state networks
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Network homogeneity reveals decreased integrity of default-mode network in ADHD. / Uddin, Lucina Q; Kelly, A. M Clare; Biswal, Bharat B.; Margulies, Daniel S.; Shehzad, Zarrar; Shaw, David; Ghaffari, Manely; Rotrosen, John; Adler, Lenard A.; Castellanos, F. Xavier; Milham, Michael P.
In: Journal of Neuroscience Methods, Vol. 169, No. 1, 30.03.2008, p. 249-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Network homogeneity reveals decreased integrity of default-mode network in ADHD
AU - Uddin, Lucina Q
AU - Kelly, A. M Clare
AU - Biswal, Bharat B.
AU - Margulies, Daniel S.
AU - Shehzad, Zarrar
AU - Shaw, David
AU - Ghaffari, Manely
AU - Rotrosen, John
AU - Adler, Lenard A.
AU - Castellanos, F. Xavier
AU - Milham, Michael P.
PY - 2008/3/30
Y1 - 2008/3/30
N2 - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
AB - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
KW - Attention
KW - Attention-deficit/hyperactivity disorder
KW - fMRI
KW - Functional connectivity
KW - Posterior cingulate
KW - Precuneus
KW - Resting state networks
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UR - http://www.scopus.com/inward/citedby.url?scp=39749202359&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2007.11.031
DO - 10.1016/j.jneumeth.2007.11.031
M3 - Article
C2 - 18190970
AN - SCOPUS:39749202359
VL - 169
SP - 249
EP - 254
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
IS - 1
ER -