TY - JOUR
T1 - Network homogeneity reveals decreased integrity of default-mode network in ADHD
AU - Uddin, Lucina Q.
AU - Kelly, A. M.Clare
AU - Biswal, Bharat B.
AU - Margulies, Daniel S.
AU - Shehzad, Zarrar
AU - Shaw, David
AU - Ghaffari, Manely
AU - Rotrosen, John
AU - Adler, Lenard A.
AU - Castellanos, F. Xavier
AU - Milham, Michael P.
PY - 2008/3/30
Y1 - 2008/3/30
N2 - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
AB - Examination of spontaneous intrinsic brain activity is drawing increasing interest, thus methods for such analyses are rapidly evolving. Here we describe a novel measure, "network homogeneity", that allows for assessment of cohesiveness within a specified functional network, and apply it to resting-state fMRI data from adult ADHD and control participants. We examined the default mode network, a medial-wall based network characterized by high baseline activity that decreases during attention-demanding cognitive tasks. We found reduced network homogeneity within the default mode network in ADHD subjects compared to age-matched controls, particularly between the precuneus and other default mode network regions. This confirms previously published results using seed-based functional connectivity measures, and provides further evidence that altered precuneus connectivity is involved in the neuropathology of ADHD. Network homogeneity provides a potential alternative method for assessing functional connectivity of specific large-scale networks in clinical populations.
KW - Attention
KW - Attention-deficit/hyperactivity disorder
KW - Functional connectivity
KW - Posterior cingulate
KW - Precuneus
KW - Resting state networks
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=39749202359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39749202359&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2007.11.031
DO - 10.1016/j.jneumeth.2007.11.031
M3 - Article
C2 - 18190970
AN - SCOPUS:39749202359
VL - 169
SP - 249
EP - 254
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
IS - 1
ER -