Network convergence zones in the anterior midcingulate cortex

Daniel S. Margulies, Lucina Q. Uddin

Research output: Chapter in Book/Report/Conference proceedingChapter


Situated medially and centrally in the brain, the anterior midcingulate cortex (aMCC) is a nexus of control. This specialized neocortical brain region participates in large-scale brain networks underlying attention, motor, and limbic processes. The functional diversity and proximity of cognitive and affective subdivisions within this region are its distinguishing features, rendering it an effective site for integration across domains. Here we review comparative neuroanatomic, meta-analytic, and connectomic analyses contributing to the emerging picture of the aMCC as comprising functionally diverse, flexible network nodes involved in multiple regulatory behaviors. We further present data providing evidence for an organizing gradient along the anterior and midcingulate cortex and explore the implications of these findings for understanding the functional role of the anterior midcingulate within this spectrum. We conclude by highlighting open questions and proposing future directions for investigations into the functional role of this important network convergence zone.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Number of pages9
StatePublished - 2019
Externally publishedYes

Publication series

NameHandbook of Clinical Neurology
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152



  • Comparative anatomy
  • Functional connectivity
  • Gradients
  • Parcellation
  • Resting-state fMRI
  • Salience network

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Margulies, D. S., & Uddin, L. Q. (2019). Network convergence zones in the anterior midcingulate cortex. In Handbook of Clinical Neurology (pp. 103-111). (Handbook of Clinical Neurology; Vol. 166). Elsevier B.V..