Abstract
Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 625-633 |
| Number of pages | 9 |
| Journal | Experimental Neurology |
| Volume | 77 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1982 |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Nerve growth factor effects on protein synthesis after nerve damage. / Hall, Michael E.; Wilson, David L.
In: Experimental Neurology, Vol. 77, No. 3, 01.01.1982, p. 625-633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nerve growth factor effects on protein synthesis after nerve damage
AU - Hall, Michael E.
AU - Wilson, David L.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.
AB - Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.
UR - http://www.scopus.com/inward/record.url?scp=0019924597&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019924597&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(82)90233-3
DO - 10.1016/0014-4886(82)90233-3
M3 - Article
C2 - 7117466
AN - SCOPUS:0019924597
VL - 77
SP - 625
EP - 633
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 3
ER -