Nerve growth factor effects on protein synthesis after nerve damage

Michael E. Hall, David L. Wilson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.

Original languageEnglish
Pages (from-to)625-633
Number of pages9
JournalExperimental Neurology
Volume77
Issue number3
DOIs
StatePublished - Jan 1 1982

Fingerprint

Nerve Growth Factor
Retrograde Degeneration
Axotomy
Superior Cervical Ganglion
Sympathetic Ganglia
Proteins
Electrophoresis, Gel, Two-Dimensional
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Nerve growth factor effects on protein synthesis after nerve damage. / Hall, Michael E.; Wilson, David L.

In: Experimental Neurology, Vol. 77, No. 3, 01.01.1982, p. 625-633.

Research output: Contribution to journalArticle

Hall, Michael E. ; Wilson, David L. / Nerve growth factor effects on protein synthesis after nerve damage. In: Experimental Neurology. 1982 ; Vol. 77, No. 3. pp. 625-633.
@article{88a85f7639764b43bbe4d8e9152d8606,
title = "Nerve growth factor effects on protein synthesis after nerve damage",
abstract = "Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.",
author = "Hall, {Michael E.} and Wilson, {David L.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/0014-4886(82)90233-3",
language = "English",
volume = "77",
pages = "625--633",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Nerve growth factor effects on protein synthesis after nerve damage

AU - Hall, Michael E.

AU - Wilson, David L.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.

AB - Axonal damage can induce a variety of changes in the cell bodies of neurons and in neighboring cells. Such changes, termed the axon reaction, can include neuronal chromatolysis, synaptic disconnection, and altered protein synthesis. Nerve growth factor (NGF) treatment of sympathetic ganglia after nerve damage has been reported to block partially both chromatolysis and synaptic disconnection. We examined the proteins synthesized in rat superior cervical ganglia using two-dimensional polyacrylamide gel electrophoresis. Axotomy induces changes in the relative rates of synthesis of a number of the proteins. The NGF treatment after axotomy does not reverse most of these, and induces other changes. It thus appears that the absence of NFG in retrograde transport from target tissues cannot alone be the signal for the axon reaction.

UR - http://www.scopus.com/inward/record.url?scp=0019924597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019924597&partnerID=8YFLogxK

U2 - 10.1016/0014-4886(82)90233-3

DO - 10.1016/0014-4886(82)90233-3

M3 - Article

C2 - 7117466

AN - SCOPUS:0019924597

VL - 77

SP - 625

EP - 633

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 3

ER -