Nersseria gonorrhoeae Keratoconjunctivitis

Saul Ullman, Thomas J. Roussel, William W. Culbertson, Richard K. Forster, Eduardo Alfonso, Alan D. Mendelsohn, David G. Heidemann, Simon P. Holland

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Clinical and laboratory findings of 47 patients with ocular infections secondary to Neisseria gonorrhoeae during a 5 1/2 -year period were reviewed. In 16 patients (34%), corneal involvement was noted. Six of these patients had a severe ulcerative keratitis resulting in permanent visual loss and five required surgery for a corneal perforation. Patients with corneal involvement were older and presented later in the course of their disease than patients with isolated conjunctival involvement (P < 0.005). An out-patient regimen of intramuscular antibiotics (either penicillin, cephalosporin, or spectinomycin [Trobicin]) appeared to be effective for infections limited to the conjunctiva in adults. If a topical antibiotic ointment is used in addition to parenteral antimicrobial agents, the authors' laboratory sensitivities suggest that erythromycin may be the drug of choice.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
Issue number5
StatePublished - 1987


  • Neisseria gonorrhoeae
  • gonococcal keratoconjunctivitis
  • hyperacute purulent conjunctivitis

ASJC Scopus subject areas

  • Ophthalmology


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