Nephropathy associated with sickle cell anemia

An autologous immune complex nephritis. I. Studies on nature of glomerular-bound antibody and antigen identification in a patient with sickle cell disease and immune deposit glomerulonephritis

Jose Strauss, Victoriano Pardo, Michael N. Koss, William Griswold, Rawle M. McIntosh

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Abstract

The nature of the glomerular-bound antibody and the putative antigen was investigated in one of the patients with sickle cell disease and immune deposit membranoproliferative glomerulonephritis by immunohistologic and glomerular antibody elution. Renal proximal tubular epithelial antigen was localized in association with immunoglobulins G (IgG), M (IgM), Clq fraction of the first component of complement (Clq) and the third component of complement (C3) in a granular pattern along the glomerular basement membrane of the patient's kidney. IgG and IgM were eluted from glomeruli. These immunoglobulins fixed to the proximal tubules of normal human kidney by direct immunofluorescence. This localization was abolished by absorption of the eluted immunoglobulins with renal tubular epithelial (RTE) antigen. The IgG eluted from the glomeruli blocked the fixation of rabbit anti-RTE antigen to normal proximal tubular brush border. These studies suggest that the nephritis in this patient was due to deposition of complexes of RTE antigen and specific antibody. An autologous immune complex nephritis may develop in some patients with sickle cell anemia secondary to RTE antigen released possibly after renal ischemia or some other phenomenon causing renal tubular damage.

Original languageEnglish
Pages (from-to)382-387
Number of pages6
JournalThe American Journal of Medicine
Volume58
Issue number3
DOIs
StatePublished - Jan 1 1975

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Nephritis
Sickle Cell Anemia
Glomerulonephritis
Antigen-Antibody Complex
Antigens
Immunoglobulin G
Antibodies
Kidney
Immunoglobulins
Membranoproliferative Glomerulonephritis
Direct Fluorescent Antibody Technique
Glomerular Basement Membrane
Complement C3
Microvilli
Immunoglobulin M
Ischemia
renal tubular antigen
Rabbits

ASJC Scopus subject areas

  • Nursing(all)

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Nephropathy associated with sickle cell anemia : An autologous immune complex nephritis. I. Studies on nature of glomerular-bound antibody and antigen identification in a patient with sickle cell disease and immune deposit glomerulonephritis. / Strauss, Jose; Pardo, Victoriano; Koss, Michael N.; Griswold, William; McIntosh, Rawle M.

In: The American Journal of Medicine, Vol. 58, No. 3, 01.01.1975, p. 382-387.

Research output: Contribution to journalArticle

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