Neonatal syndromes of polyendocrinopathy

Francesco Dotta, Francesco Vendrame

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Fetal and newborn mammals have a limited ability to mount an immune response, both qualitatively and quantitatively, leading to an increased susceptibility to bacterial or viral infections. The incomplete development in the neonate of both innate and acquired immune system may well explain this increased susceptibility; however, the neonatal immune system, under certain circumstances, can mount an efficient immune response. Various immunemediated disorders, including autoimmune syndromes, can take place in the early postnatal life, a period during which the immune system acquires key functions and undergoes a complex maturation and education process. Neonatal autoimmune syndromes involving endocrine glands include: IPEX/XLAAD/XPID, neonatal hyperthyroidism, Di George syndrome, ALPS, and Kabuki syndrome.

Original languageEnglish (US)
Pages (from-to)283-293
Number of pages11
JournalEndocrinology and Metabolism Clinics of North America
Volume31
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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