Neonatal fat digestion and lingual lipase

Lesley J Smith, S. Kaminsky, S. W. D'Souza

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Lingual lipase (LL) activity, pH, and products of fat hydrolysis were determined in gastric aspirates from preterm infants who received formula milk feeds by a nasogastric tube. In 1-hourly (n=9), 2-hourly (n=8) and 3-hourly (n=9) fed infants LL activity increased to reach its maximum value at 60, 90, and 120 min respectively after the feeds, and gastric pH levels fell from about 6.0 to <3.5. There was a reduction in triglyceride content to 50% of the initial value, measured immediately after a feed, and the products of hydrolysis were mainly diglycerides and FFA. In a subsequent study 3-hourly fed infants (n=8) had a feed followed by a bottle feed, and then a bottle feed followed by a tube feed on successive days (cross-over). The LL activity observed after a bottle feed (mean maximal value 23.8 μmol FFA/ml/h) was significantly higher than after a tube feed (19.1 μmol FFA/ml/h). It is suggested that substantial triglyceride hydrolysis takes place in the stomach due to lingual lipase, and sucking seems to enhance enzyme production.

Original languageEnglish
Pages (from-to)913-918
Number of pages6
JournalActa Paediatrica Scandinavica
Volume75
Issue number6
StatePublished - Dec 1 1986
Externally publishedYes

Fingerprint

Lipase
Tongue
Digestion
Fats
Stomach
Hydrolysis
Triglycerides
Diglycerides
Premature Infants
Milk
Enzymes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Smith, L. J., Kaminsky, S., & D'Souza, S. W. (1986). Neonatal fat digestion and lingual lipase. Acta Paediatrica Scandinavica, 75(6), 913-918.

Neonatal fat digestion and lingual lipase. / Smith, Lesley J; Kaminsky, S.; D'Souza, S. W.

In: Acta Paediatrica Scandinavica, Vol. 75, No. 6, 01.12.1986, p. 913-918.

Research output: Contribution to journalArticle

Smith, LJ, Kaminsky, S & D'Souza, SW 1986, 'Neonatal fat digestion and lingual lipase', Acta Paediatrica Scandinavica, vol. 75, no. 6, pp. 913-918.
Smith LJ, Kaminsky S, D'Souza SW. Neonatal fat digestion and lingual lipase. Acta Paediatrica Scandinavica. 1986 Dec 1;75(6):913-918.
Smith, Lesley J ; Kaminsky, S. ; D'Souza, S. W. / Neonatal fat digestion and lingual lipase. In: Acta Paediatrica Scandinavica. 1986 ; Vol. 75, No. 6. pp. 913-918.
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