Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization in rats

Paola I. Ingaramo, Jorgelina Varayoud, María M. Milesi, Marlise Guerrero Schimpf, Ramiro Alarcón, Mónica Muñoz-de-Toro, Enrique H. Luque

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We investigated whether defective modulation of uterine signaling may cause decidualization failure in rats neonatally exposed to a glyphosate-based herbicide (GBH). Female pups received vehicle or 2 mg/kg of GBH from postnatal day (PND) 1 to PND7. On PND8 and PND21, Wnt5a and β-catenin expression was evaluated in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and β-catenin expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, GBH-exposed rats showed increased Wnt5a and β-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and β-catenin expression in subepithelial stroma but decreased β-catenin expression in glandular epithelium. On GD9, GBH-exposed rats showed decreased Wnt5a and Wnt7a expression in the antimesometrial zone and LE respectively, without changes in β-catenin expression, while Dkk1 and sFRP4 were up- and down-regulated respectively. We concluded that neonatal GBH exposure may lead to embryo losses by disturbing uterine signaling.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalReproductive Toxicology
Volume73
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • Decidualization
  • Dkk1
  • Glyphosate-based herbicide
  • Implantation sites
  • sFRP4
  • Wnt5a
  • Wnt7a
  • β-catenin

ASJC Scopus subject areas

  • Toxicology

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