Neomycin-Induced Steatorrhea: A Preliminary Report on the in Vivo Hydrolysis of a Long-Chain Unsaturated Fat

Arvey I. Rogers, Derk A. Vloedman, Eugene C. Bloom, Martin H. Kalser

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Malabsorption was induced in two adult patients by the prolonged oral administration of neomycin sulfate. Histopathologic small-bowel changes and altered chemical indices of absorption characterized the malabsorptive state. A defect in the hydrolysis of a long-chain unsaturated fat (triolein) was demonstrated by analysis of fat meals aspirated from the duodenojejunal junction. The pathogenesis of the hydrolytic defect is unknown but, theoretically, is related to either the absorptive defect imposed by the associated intestinal cellular damage or a direct inhibition of lipase action by neomycin.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume197
Issue number3
DOIs
StatePublished - Jul 18 1966

ASJC Scopus subject areas

  • Medicine(all)

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