Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia

J. V. Haxby, C. L. Grady, R. Duara, N. Schlageter, G. Berg, S. I. Rapoport

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Neuropsychological function and resting regional neocortical glucose metabolism, as measured by positron-emission tomography, were studied in 22 patients with mild and moderate Alzheimer's-type dementia. Metabolic reductions in the parietal association cortex and increased left-right metabolic asymmetry were observed in patients with mild and moderate degrees of dementia. Five patients with mild dementia had no impairment of neocortically mediated neuropsychological function, yet they demonstrated these same neocortical metabolic abnormalities. Asymmetry of neocortically mediated, neuropsychological functions correlated with metabolic asymmetries in patients with moderate but not mild dementia. These results suggest that physiological dysfunction in the association neocortex is evident in early Alzheimer's-type dementia before the neuropsychological consequences of that dysfunction are demonstrable.

Original languageEnglish
Pages (from-to)882-885
Number of pages4
JournalArchives of Neurology
Volume43
Issue number9
StatePublished - Oct 22 1986
Externally publishedYes

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Alzheimer Disease
Dementia
Parietal Lobe
Neocortex
Positron-Emission Tomography
Glucose
Defects
Alzheimer
Asymmetry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Haxby, J. V., Grady, C. L., Duara, R., Schlageter, N., Berg, G., & Rapoport, S. I. (1986). Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. Archives of Neurology, 43(9), 882-885.

Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. / Haxby, J. V.; Grady, C. L.; Duara, R.; Schlageter, N.; Berg, G.; Rapoport, S. I.

In: Archives of Neurology, Vol. 43, No. 9, 22.10.1986, p. 882-885.

Research output: Contribution to journalArticle

Haxby, JV, Grady, CL, Duara, R, Schlageter, N, Berg, G & Rapoport, SI 1986, 'Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia', Archives of Neurology, vol. 43, no. 9, pp. 882-885.
Haxby JV, Grady CL, Duara R, Schlageter N, Berg G, Rapoport SI. Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. Archives of Neurology. 1986 Oct 22;43(9):882-885.
Haxby, J. V. ; Grady, C. L. ; Duara, R. ; Schlageter, N. ; Berg, G. ; Rapoport, S. I. / Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementia. In: Archives of Neurology. 1986 ; Vol. 43, No. 9. pp. 882-885.
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