Neocortical Metabolic Abnormalities Precede Nonmemory Cognitive Defects in Early Alzheimer's-Type Dementia

James V. Haxby, Cheryl L. Grady, Ranjan Duara, Nicholas Schlageter, Gary Berg, Stanley I. Rapoport

Research output: Contribution to journalArticle

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Neuropsychological function and resting regional neocortical glucose metabolism, as measured by positron-emission tomography, were studied in 22 patients with mild and moderate Alzheimer's-type dementia. Metabolic reductions in the parietal association cortex and increased left-right metabolic asymmetry were observed in patients with mild and moderate degrees of dementia. Five patients with mild dementia had no impairment of neocortically mediated neuropsychological function, yet they demonstrated these same neocortical metabolic abnormalities. Asymmetry of neocortically mediated, neuropsychological functions correlated with metabolic asymmetries in patients with moderate but not mild dementia. These results suggest that physiological dysfunction in the association neocortex is evident in early Alzheimer's-type dementia before the neuropsychological consequences of that dysfunction are demonstrable.

Original languageEnglish (US)
Pages (from-to)882-885
Number of pages4
JournalArchives of neurology
Issue number9
StatePublished - Sep 1986


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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