Neoadjuvant therapy for gastric cancer: Current evidence and future directions

Andrew D. Newton, Jashodeep Datta, Arturo Loaiza-Bonilla, Giorgos C. Karakousis, Robert E. Roses

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Although surgical resection remains the only potentially curative treatment for gastric cancer (GC), poor long-term outcomes with resection alone compel a multimodality approach to this disease. Multimodality strategies vary widely; while adjuvant approaches are typically favored in Asia and the United States (USA), a growing body of evidence supports neoadjuvant and/or perioperative strategies in locally advanced tumors. Neoadjuvant approaches are particularly attractive given the morbidity associated with surgical management of GC and the substantial risk of omission of adjuvant therapy. The specific advantages of chemoradiotherapy (CRT) compared to chemotherapy have not been well defined, particularly in the preoperative setting and trials aimed at determining the optimal elements and sequencing of therapy are underway. Future studies will also define the role of targeted and biologic therapies.

Original languageEnglish (US)
Pages (from-to)534-543
Number of pages10
JournalJournal of Gastrointestinal Oncology
Volume6
Issue number5
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Chemoradiotherapy (CRT)
  • Chemotherapy
  • Gastric cancer (GC)
  • Multimodality therapy
  • neoadjuvant therapy
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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