PURPOSE OF REVIEW: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract and is a paradigm of targeted therapy for solid tumors. Elucidation of the biology of GIST enabled use of imatinib, which revolutionized the prognosis of advanced GIST. Whereas surgical resection continues to be the standard of care for primary GIST, judicious and individualized use of adjuvant and neoadjuvant imatinib may enhance the potential for cure in select patients. RECENT FINDINGS: Prospective trials utilizing adjuvant and neoadjuvant imatinib have established the safety and efficacy of these modalities adjunct to surgical resection. Correlative tissue studies derived from these trials have examined gene expression patterns, metabolic and radiographic response, and apoptosis during the first few days of imatinib therapy. As appropriate use of adjuvant and neoadjuvant imatinib requires proper patient selection, development of a predictive nomogram, and advances in mutational analysis represent progress toward individualized care. SUMMARY: Imatinib is well tolerated and beneficial as adjuvant and neoadjuvant therapy, but its utility in these settings continues to be refined. The greatest benefit will derive from an individualized approach that considers multiple patient, drug, and tumor characteristics to assess risk and likelihood of benefit for each patient.
ASJC Scopus subject areas
- Cancer Research
Neoadjuvant and adjuvant imatinib treatment in gastrointestinal stromal tumor : Current status and recent developments. / Reynoso, David; Trent, Jonathan.In: Current Opinion in Oncology, Vol. 22, No. 4, 01.07.2010, p. 330-335.
Research output: Contribution to journal › Article
TY - JOUR
T1 - Neoadjuvant and adjuvant imatinib treatment in gastrointestinal stromal tumor
T2 - Current status and recent developments
AU - Reynoso, David
AU - Trent, Jonathan
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Lippincott Williams &Wilkins.
AB - Lippincott Williams &Wilkins.
KW - adjuvant
KW - GIST
KW - imatinib
KW - neoadjuvant
UR - http://www.scopus.com/inward/record.url?scp=77953960843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953960843&partnerID=8YFLogxK
U2 - 10.1097/CCO.0b013e32833aaaad
DO - 10.1097/CCO.0b013e32833aaaad
M3 - Article
C2 - 20520542
AN - SCOPUS:77953960843
VL - 22
SP - 330
EP - 335
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
SN - 1040-8746
IS - 4