Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer: The likelihood of initiation and completion

Ahmed Eldefrawy, Mark S. Soloway, Devendar Katkoori, Rakesh Singal, David Pan, Murugesan Manoharan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Chemotherapy was shown to improve survival in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The initiation and completion rates for perioperative chemotherapy are variable. Our aim is to compare the likelihood of initiating and completing neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients who underwent of RC for MIBC. Materials and Methods: We performed a retrospective analysis of patients who underwent RC between 1992 and 2011. NAC was advised for patients with clinical stage ≥T2, hydronephrosis, extensive lymphovascular invasion (LVI), or prostatic stromal invasion. Patients with ≥pT3 or lymph node metastases were considered for AC. Results: A total of 363 patients were considered for perioperative chemotherapy. Among the 141 patients who were offered NAC, 125 (88.6%) initiated NAC. A total of 222 were considered for AC, and 151 (68.0%) initiated AC (P < 0.001). In the NAC group, 118 (83.5%) completed planned number of cycles of chemotherapy and 7 (5.6%) did not complete the planned chemotherapy. In the AC group, 79 (35.5%) completed at least four cycles and 72 (47.3%) could not complete the planned cycles (P < 0.001). Conclusions: Patients with MIBC are more likely to initiate and complete NAC than AC.

Original languageEnglish
Pages (from-to)424-426
Number of pages3
JournalIndian Journal of Urology
Volume28
Issue number4
DOIs
StatePublished - Oct 1 2012

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Adjuvant Chemotherapy
Urinary Bladder Neoplasms
Muscles
Cystectomy
Drug Therapy
Hydronephrosis
Lymph Nodes
Neoplasm Metastasis
Survival

Keywords

  • Adjuvant
  • bladder cancer
  • chemotherapy
  • completion
  • neoadjuvant
  • radical cystectomy

ASJC Scopus subject areas

  • Urology

Cite this

Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer : The likelihood of initiation and completion. / Eldefrawy, Ahmed; Soloway, Mark S.; Katkoori, Devendar; Singal, Rakesh; Pan, David; Manoharan, Murugesan.

In: Indian Journal of Urology, Vol. 28, No. 4, 01.10.2012, p. 424-426.

Research output: Contribution to journalArticle

Eldefrawy, Ahmed ; Soloway, Mark S. ; Katkoori, Devendar ; Singal, Rakesh ; Pan, David ; Manoharan, Murugesan. / Neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer : The likelihood of initiation and completion. In: Indian Journal of Urology. 2012 ; Vol. 28, No. 4. pp. 424-426.
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abstract = "Introduction: Chemotherapy was shown to improve survival in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The initiation and completion rates for perioperative chemotherapy are variable. Our aim is to compare the likelihood of initiating and completing neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients who underwent of RC for MIBC. Materials and Methods: We performed a retrospective analysis of patients who underwent RC between 1992 and 2011. NAC was advised for patients with clinical stage ≥T2, hydronephrosis, extensive lymphovascular invasion (LVI), or prostatic stromal invasion. Patients with ≥pT3 or lymph node metastases were considered for AC. Results: A total of 363 patients were considered for perioperative chemotherapy. Among the 141 patients who were offered NAC, 125 (88.6{\%}) initiated NAC. A total of 222 were considered for AC, and 151 (68.0{\%}) initiated AC (P < 0.001). In the NAC group, 118 (83.5{\%}) completed planned number of cycles of chemotherapy and 7 (5.6{\%}) did not complete the planned chemotherapy. In the AC group, 79 (35.5{\%}) completed at least four cycles and 72 (47.3{\%}) could not complete the planned cycles (P < 0.001). Conclusions: Patients with MIBC are more likely to initiate and complete NAC than AC.",
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AU - Pan, David

AU - Manoharan, Murugesan

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N2 - Introduction: Chemotherapy was shown to improve survival in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The initiation and completion rates for perioperative chemotherapy are variable. Our aim is to compare the likelihood of initiating and completing neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients who underwent of RC for MIBC. Materials and Methods: We performed a retrospective analysis of patients who underwent RC between 1992 and 2011. NAC was advised for patients with clinical stage ≥T2, hydronephrosis, extensive lymphovascular invasion (LVI), or prostatic stromal invasion. Patients with ≥pT3 or lymph node metastases were considered for AC. Results: A total of 363 patients were considered for perioperative chemotherapy. Among the 141 patients who were offered NAC, 125 (88.6%) initiated NAC. A total of 222 were considered for AC, and 151 (68.0%) initiated AC (P < 0.001). In the NAC group, 118 (83.5%) completed planned number of cycles of chemotherapy and 7 (5.6%) did not complete the planned chemotherapy. In the AC group, 79 (35.5%) completed at least four cycles and 72 (47.3%) could not complete the planned cycles (P < 0.001). Conclusions: Patients with MIBC are more likely to initiate and complete NAC than AC.

AB - Introduction: Chemotherapy was shown to improve survival in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The initiation and completion rates for perioperative chemotherapy are variable. Our aim is to compare the likelihood of initiating and completing neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients who underwent of RC for MIBC. Materials and Methods: We performed a retrospective analysis of patients who underwent RC between 1992 and 2011. NAC was advised for patients with clinical stage ≥T2, hydronephrosis, extensive lymphovascular invasion (LVI), or prostatic stromal invasion. Patients with ≥pT3 or lymph node metastases were considered for AC. Results: A total of 363 patients were considered for perioperative chemotherapy. Among the 141 patients who were offered NAC, 125 (88.6%) initiated NAC. A total of 222 were considered for AC, and 151 (68.0%) initiated AC (P < 0.001). In the NAC group, 118 (83.5%) completed planned number of cycles of chemotherapy and 7 (5.6%) did not complete the planned chemotherapy. In the AC group, 79 (35.5%) completed at least four cycles and 72 (47.3%) could not complete the planned cycles (P < 0.001). Conclusions: Patients with MIBC are more likely to initiate and complete NAC than AC.

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