Negative impact of new-onset diabetes mellitus on patient and graft survival after liver transplantation: Long-term follow up

Jang I. Moon, Ralph Barbeito, Raquel N. Faradji, Jeffrey Gaynor, Andreas G. Tzakis

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115 Scopus citations

Abstract

BACKGROUND. Little is known about the long-term consequences of new-onset diabetes mellitus (NODM) after liver transplantation (LTX). METHODS. In a chart review between 1996 and 2004, we evaluated its incidence and possible effect on patient and graft survival. Inclusion criteria were: adult primary LTX; deceased donor LTX without combined organs; and dual immunosuppression with tacrolimus and corticosteroid. Patients who died within six months after LTX were excluded. For analytical purposes, each patient was classified into one of four groups: 1) preLTX diabetes mellitus (DM): established DM before LTX; 2) sustained NODM: NODM sustained ≥6 months; 3) transitory NODM: NODM temporarily existed ≥1 and <6 months; and 4) normal: no DM either pre- or postLTX. Patients who had NODM <1 month due to high-dose steroid (e.g., either immediate postLTX or rejection treatment) were considered as normal. Patient and graft survival was examined using Kaplan-Meier methodology. RESULTS. In all, 778 patients met the inclusion/exclusion criteria: preLTX DM 159 (20.4%), sustained NODM 284 (36.5%), transitory NODM 108 (13.9%), and normal 227 (29.2%). Median follow-up was 57.2 months. There was a significant difference in patient (P=0.012) and graft survival (P=0.004) among the groups, with sustained NODM showing the poorest patient and graft survivals. Sustained NODM patients had a significantly higher rate of death due to infection, as well as graft failure due to chronic rejection and late onset hepatic artery thrombosis. CONCLUSION. NODM is a frequent complication with poor patient and graft survival after LTX.

Original languageEnglish
Pages (from-to)1625-1628
Number of pages4
JournalTransplantation
Volume82
Issue number12
DOIs
StatePublished - Dec 1 2006

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Keywords

  • Incidence
  • Liver transplantation
  • New-onset diabetes mellitus
  • Patient and graft survival

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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