TY - JOUR
T1 - Necrotizing granulomas in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
AU - Blanco, Mario
AU - Ratzan, Judith
AU - Cabello-Inchausti, Beria
AU - Fernandes, Lianne
PY - 2002/8
Y1 - 2002/8
N2 - We present three cases of patients with B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia that were retrieved from our files during a period of 11 months and who suddenly developed lymphadenopathy. Clinically, this lymphadenopathy was thought to represent a manifestation of their background disease and, for this reason, no cultures were performed on fresh tissue. However, histologic studies in all cases showed necrotizing granulomas. When results of our special stains were negative, we submitted the specimens for molecular studies, which demonstrated the presence of tuberculous bacilli in two out of three cases. We believe that tuberculosis can present as a sudden lymphadenopathy in immunocompromised people and we would like to raise the awareness among the clinicians and nursing and pathology laboratory staff about the risks of handling these specimens without proper precautions. Also, we emphasize the fact that, in some cases, tuberculous bacilli cases may need molecular studies to be demonstrated.
AB - We present three cases of patients with B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia that were retrieved from our files during a period of 11 months and who suddenly developed lymphadenopathy. Clinically, this lymphadenopathy was thought to represent a manifestation of their background disease and, for this reason, no cultures were performed on fresh tissue. However, histologic studies in all cases showed necrotizing granulomas. When results of our special stains were negative, we submitted the specimens for molecular studies, which demonstrated the presence of tuberculous bacilli in two out of three cases. We believe that tuberculosis can present as a sudden lymphadenopathy in immunocompromised people and we would like to raise the awareness among the clinicians and nursing and pathology laboratory staff about the risks of handling these specimens without proper precautions. Also, we emphasize the fact that, in some cases, tuberculous bacilli cases may need molecular studies to be demonstrated.
KW - Necrotizing granulomas
KW - Nucleic acid amplified myco-bacterium tuberculosis direct test
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=0036667566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036667566&partnerID=8YFLogxK
U2 - 10.1053/adpa.2002.34730
DO - 10.1053/adpa.2002.34730
M3 - Article
C2 - 12170452
AN - SCOPUS:0036667566
VL - 6
SP - 216
EP - 221
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
SN - 1092-9134
IS - 4
ER -
