Necrotizing enterocolitis in full-term or near-term infants: Risk factors

Emilia Martinez-Tallo, Nelson Claure, Eduardo Bancalari

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


A retrospective case-control study of necrotizing enterocolitis (NEC) affecting infants weighing > 2000 g at birth was performed to determine those factors which could contribute to the development of NEC. Twenty-four infants met the criteria of definite NEC. For each case the next 2 healthy newborns were matched as controls. When compared with the control group, NEC infants had a significantly higher frequency of prolonged rupture of membranes, chorioamnionitis, Apgar score < 7 at 1 and 5 min, respiratory problems, congenital heart disease, hypoglycemia, and exchange transfusions. Only 3 infants with NEC were healthy newborns with an unremarkable perinatal course before NEC. There were no differences in the frequency of preeclampsia, maternal diabetes, maternal drug abuse, meconium-stained amniotic fluid and polycythemia. These results indicate that most of these more mature infants have a predisposing factor before developing NEC.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
Issue number5
StatePublished - Jan 1 1997


  • Necrotizing enterocolitis
  • Pseudomembranous enterocolitis

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health


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