Naturally occurring compounds as pancreatic cancer therapeutics

Ines Lohse, Erin Wildermuth, Shaun P. Brothers

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Naturally occurring small molecule compounds have long been in the spotlight of pancreatic cancer research as potential therapeutics to prevent cancer progression and sensitize chemoresistant tumors. The hope is that terminal pancreatic cancer patients receiving aggressive chemotherapy can benefit from an increase in treatment efficacy without adding further toxicity by way of utilizing natural compounds. While preclinical studies on a number of natural compounds, such as resveratrol, curcumin, rapalogs and cannabinoids, show promising preclinical results, little has translated into clinical practice, though a number of other compounds hold clinical potential. Nevertheless, recent advances in compound formulation may increase the clinical utility of these compounds.

Original languageEnglish (US)
Pages (from-to)35448-35457
Number of pages10
JournalOncotarget
Volume9
Issue number83
DOIs
StatePublished - Oct 1 2018

Keywords

  • Curcumin
  • Natural compounds
  • Pancreatic cancer
  • Resveratrol
  • Taxane

ASJC Scopus subject areas

  • Oncology

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