Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination

Yi Zeng, Xinchun Chen, Nicolas Larmonier, Claire Larmonier, Gang Li, Marjan Sepassi, Marilyn Marron, Samita Andreansky, Emmanuel Katsanis

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Tumor derived chaperone-rich cell lysate (CRCL) when isolated from tumor tissues is a potent vaccine that contains at least 4 of the highly immunogenic heat shock proteins (HSP) such as HSP70, HSP90, glucose related protein 94 and calreticulin. We have previously documented that CRCL provides both a source of tumor antigens and danger signals triggering dendritic cell (DC) activation. Immunization with tumor derived CRCL elicits tumor-specific T cell responses leading to tumor regression. In the current study, we further dissect the mechanisms by which CRCL simulates the immune system, and demonstrate that natural killer (NK) cells are required for effective antitumor effects to take place. Our results illustrate that CRCL directly stimulates proinflammatory cytokine and chemokine production by NK cells, which may lead to activation and recruitment of macrophages at the tumor site. Thus, this report provides further insight into the function of CRCL as an immunostimulant against cancer.

Original languageEnglish (US)
Pages (from-to)2624-2631
Number of pages8
JournalInternational Journal of Cancer
Volume119
Issue number11
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • Chaperone/heat shock proteins
  • CML
  • NK cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Zeng, Y., Chen, X., Larmonier, N., Larmonier, C., Li, G., Sepassi, M., Marron, M., Andreansky, S., & Katsanis, E. (2006). Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination. International Journal of Cancer, 119(11), 2624-2631. https://doi.org/10.1002/ijc.22150