Natural history of intrahepatic canine islet cell autografts

Rodolfo Alejandro, R. G. Cutfield, F. L. Shienvold, K. S. Polonsky, J. Noel, L. Olson, J. Dillberger, J. Miller, D. H. Mintz

Research output: Contribution to journalArticle

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Abstract

We have serially followed the function of intrahepatic canine islet autografts in 15 beagle dogs for up to 24 mo. Of these, only 20% sustained normal levels of fasting blood glucose for >15 mo posttransplant. Failure of autograft function was accompanied by a preferential loss of well-granulated beta cells in the engrafted islets. The chronic stimulation of an initially marginal intrahepatic beta-cell mass ultimately resulted in metabolic deterioration and loss of beta cells below the minimal threshold required to maintain normal fasting blood glucose levels. It is possible that transplantation of a larger mass of islets would result in indefinite graft function in dogs. However, it remains to be demonstrated in larger mammals, including humans, whether an islet cell mass that is initially adequate in a heterotopic site such as the liver can remain functionally competent over a prolonged period.

Original languageEnglish
Pages (from-to)1339-1348
Number of pages10
JournalJournal of Clinical Investigation
Volume78
Issue number5
StatePublished - Dec 1 1986

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Autografts
Natural History
Islets of Langerhans
Canidae
Blood Glucose
Fasting
Dogs
Mammals
Transplantation
Transplants
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alejandro, R., Cutfield, R. G., Shienvold, F. L., Polonsky, K. S., Noel, J., Olson, L., ... Mintz, D. H. (1986). Natural history of intrahepatic canine islet cell autografts. Journal of Clinical Investigation, 78(5), 1339-1348.

Natural history of intrahepatic canine islet cell autografts. / Alejandro, Rodolfo; Cutfield, R. G.; Shienvold, F. L.; Polonsky, K. S.; Noel, J.; Olson, L.; Dillberger, J.; Miller, J.; Mintz, D. H.

In: Journal of Clinical Investigation, Vol. 78, No. 5, 01.12.1986, p. 1339-1348.

Research output: Contribution to journalArticle

Alejandro, R, Cutfield, RG, Shienvold, FL, Polonsky, KS, Noel, J, Olson, L, Dillberger, J, Miller, J & Mintz, DH 1986, 'Natural history of intrahepatic canine islet cell autografts', Journal of Clinical Investigation, vol. 78, no. 5, pp. 1339-1348.
Alejandro R, Cutfield RG, Shienvold FL, Polonsky KS, Noel J, Olson L et al. Natural history of intrahepatic canine islet cell autografts. Journal of Clinical Investigation. 1986 Dec 1;78(5):1339-1348.
Alejandro, Rodolfo ; Cutfield, R. G. ; Shienvold, F. L. ; Polonsky, K. S. ; Noel, J. ; Olson, L. ; Dillberger, J. ; Miller, J. ; Mintz, D. H. / Natural history of intrahepatic canine islet cell autografts. In: Journal of Clinical Investigation. 1986 ; Vol. 78, No. 5. pp. 1339-1348.
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