Natural history of intracranial atherosclerosis: A critical review

Ricardo J Komotar, David A. Wilson, J. Mocco, Jess E. Jones, E. Sander Connolly, Sean D. Lavine, Philip M. Meyers

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

INTRACRANIAL ATHEROSCLEROSIS IS responsible for a significant number of strokes. Medical therapy for this condition may fail, leaving patients at high risk for cerebral infarction and death. With advances in endovascular techniques on the horizon, understanding the prognosis of conservative treatment is essential for appropriate patient management. Although several small studies have attempted to address this issue, a comprehensive review regarding the natural history of intracranial atherosclerosis in a vessel-specific manner is lacking. Owing to heterogeneity in vascular anatomy and physiology, atherosclerosis in different vessels may represent diseases with fundamentally distinct courses. Therefore, it is important to distinguish vascular territories when studying the natural history of this condition. To this end, we critically review the literature investigating medical management of patients with intracranial atherosclerosis, segregating our findings by vessel. Analysis by this method suggests that middle cerebral artery atherosclerosis carries a lower mortality rate than stenoses involving other intracranial vessels, and that asymptomatic disease follows a more benign course. In addition, plaque progression and transcranial Doppler-detected microemboli seem to predict outcome according to limited data. This comprehensive review may help guide clinical decision-making and therapeutic developments in this patient population.

Original languageEnglish
Pages (from-to)595-601
Number of pages7
JournalNeurosurgery
Volume58
Issue number4
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Intracranial Arteriosclerosis
Blood Vessels
Asymptomatic Diseases
Endovascular Procedures
Cerebral Infarction
Middle Cerebral Artery
Natural History
Anatomy
Atherosclerosis
Pathologic Constriction
Stroke
Mortality
Therapeutics
Population

Keywords

  • Artery
  • Atherosclerosis
  • Intracranial
  • Natural history
  • Prognosis
  • Stenosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Komotar, R. J., Wilson, D. A., Mocco, J., Jones, J. E., Connolly, E. S., Lavine, S. D., & Meyers, P. M. (2006). Natural history of intracranial atherosclerosis: A critical review. Neurosurgery, 58(4), 595-601. https://doi.org/10.1227/01.NEU.0000204102.88016.33

Natural history of intracranial atherosclerosis : A critical review. / Komotar, Ricardo J; Wilson, David A.; Mocco, J.; Jones, Jess E.; Connolly, E. Sander; Lavine, Sean D.; Meyers, Philip M.

In: Neurosurgery, Vol. 58, No. 4, 01.04.2006, p. 595-601.

Research output: Contribution to journalArticle

Komotar, RJ, Wilson, DA, Mocco, J, Jones, JE, Connolly, ES, Lavine, SD & Meyers, PM 2006, 'Natural history of intracranial atherosclerosis: A critical review', Neurosurgery, vol. 58, no. 4, pp. 595-601. https://doi.org/10.1227/01.NEU.0000204102.88016.33
Komotar RJ, Wilson DA, Mocco J, Jones JE, Connolly ES, Lavine SD et al. Natural history of intracranial atherosclerosis: A critical review. Neurosurgery. 2006 Apr 1;58(4):595-601. https://doi.org/10.1227/01.NEU.0000204102.88016.33
Komotar, Ricardo J ; Wilson, David A. ; Mocco, J. ; Jones, Jess E. ; Connolly, E. Sander ; Lavine, Sean D. ; Meyers, Philip M. / Natural history of intracranial atherosclerosis : A critical review. In: Neurosurgery. 2006 ; Vol. 58, No. 4. pp. 595-601.
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