Natural antisense transcripts mediate regulation of gene expression

Marco Magistri, Mohammad A Faghihi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and posttranscriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Original languageEnglish (US)
Title of host publicationFrom Nucleic Acids Sequences to Molecular Medicine
PublisherSpringer Berlin Heidelberg
Pages247-274
Number of pages28
ISBN (Electronic)9783642274268
ISBN (Print)9783642274251
DOIs
StatePublished - Jan 1 2012

Keywords

  • lncRNAs
  • NATs
  • Natural antisense transcripts
  • ncRNAs
  • noncoding RNAs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Magistri, M., & Faghihi, M. A. (2012). Natural antisense transcripts mediate regulation of gene expression. In From Nucleic Acids Sequences to Molecular Medicine (pp. 247-274). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-27426-8_10