Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and posttranscriptional gene regulatory mechanisms to carry out a wide variety of biological roles.
- Natural antisense transcripts
- noncoding RNAs
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)