Natural antisense transcripts

Olga Khorkova, Amanda J Myers, Jane Hsiao, Claes R Wahlestedt

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously thought to be 'junk DNA'. Roughly defined as non-coding regulatory RNA transcribed from the opposite strand of a coding gene locus, NATs are proving to be a heterogeneous group with high potential for therapeutic application. Here, we attempt to summarize the rapidly growing knowledge about this important non-coding RNA subclass.

Original languageEnglish
JournalHuman Molecular Genetics
Volume23
Issue numberR1
DOIs
StatePublished - Jan 1 2014

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Untranslated RNA
Intergenic DNA
Genome
RNA
Genes
Therapeutics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

Natural antisense transcripts. / Khorkova, Olga; Myers, Amanda J; Hsiao, Jane; Wahlestedt, Claes R.

In: Human Molecular Genetics, Vol. 23, No. R1, 01.01.2014.

Research output: Contribution to journalArticle

Khorkova, Olga ; Myers, Amanda J ; Hsiao, Jane ; Wahlestedt, Claes R. / Natural antisense transcripts. In: Human Molecular Genetics. 2014 ; Vol. 23, No. R1.
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