TY - JOUR
T1 - Nanotechnology inspired tools for mitochondrial dysfunction related diseases
AU - Wen, Ru
AU - Banik, Bhabatosh
AU - Pathak, Rakesh K.
AU - Kumar, Anil
AU - Kolishetti, Nagesh
AU - Dhar, Shanta
N1 - Funding Information:
This work was supported, in whole or in part, by the Department of Defense Prostate Cancer Idea award ( W81XWH-12-1-0406 ); American Heart Association National Scientist Award ( 14SDG18690009 ); National Heart, Lung, and Blood Institute of National Institutes of Health (NIH) under award number R56HL121392 ; National Institute of Neurological Disorders and Stroke of NIH under award number R01NS093314 to S.D.
Publisher Copyright:
© 2016 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.
AB - Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.
UR - http://www.scopus.com/inward/record.url?scp=84955590704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955590704&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2015.12.024
DO - 10.1016/j.addr.2015.12.024
M3 - Review article
C2 - 26776231
AN - SCOPUS:84955590704
VL - 99
SP - 52
EP - 69
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -