Nanotechnology inspired tools for mitochondrial dysfunction related diseases

Ru Wen, Bhabatosh Banik, Rakesh K. Pathak, Anil Kumar, Nagesh Kolishetti, Shanta Dhar

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.

Original languageEnglish (US)
Pages (from-to)52-69
Number of pages18
JournalAdvanced Drug Delivery Reviews
Volume99
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Nanotechnology
Mitochondria
Drug Overdose
Nanomedicine
Therapeutics
Nervous System Diseases
Drug-Related Side Effects and Adverse Reactions
Organelles
Neoplasms
Cardiovascular Diseases
Ions
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Nanotechnology inspired tools for mitochondrial dysfunction related diseases. / Wen, Ru; Banik, Bhabatosh; Pathak, Rakesh K.; Kumar, Anil; Kolishetti, Nagesh; Dhar, Shanta.

In: Advanced Drug Delivery Reviews, Vol. 99, 01.04.2016, p. 52-69.

Research output: Contribution to journalReview article

Wen, Ru ; Banik, Bhabatosh ; Pathak, Rakesh K. ; Kumar, Anil ; Kolishetti, Nagesh ; Dhar, Shanta. / Nanotechnology inspired tools for mitochondrial dysfunction related diseases. In: Advanced Drug Delivery Reviews. 2016 ; Vol. 99. pp. 52-69.
@article{e1b0a7034bf34a94bc21c89ba4aaa43e,
title = "Nanotechnology inspired tools for mitochondrial dysfunction related diseases",
abstract = "Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called {"}mitochondrial dysfunction related diseases{"}. One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.",
author = "Ru Wen and Bhabatosh Banik and Pathak, {Rakesh K.} and Anil Kumar and Nagesh Kolishetti and Shanta Dhar",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.addr.2015.12.024",
language = "English (US)",
volume = "99",
pages = "52--69",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Nanotechnology inspired tools for mitochondrial dysfunction related diseases

AU - Wen, Ru

AU - Banik, Bhabatosh

AU - Pathak, Rakesh K.

AU - Kumar, Anil

AU - Kolishetti, Nagesh

AU - Dhar, Shanta

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.

AB - Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.

UR - http://www.scopus.com/inward/record.url?scp=84955590704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955590704&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2015.12.024

DO - 10.1016/j.addr.2015.12.024

M3 - Review article

C2 - 26776231

AN - SCOPUS:84955590704

VL - 99

SP - 52

EP - 69

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -