Nanosensing applications of in2O3 nanowires and carbon nanotubes

Chongwu Zhou, Chao Li, Marco Curreli, Henry Lin, Fumiaki N. Ishikawa, Ram Datar, Richard J. Cote, Mark E. Thompson

Research output: Contribution to journalConference articlepeer-review

Abstract

We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.

Original languageEnglish (US)
Article number60080F
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume6008
DOIs
StatePublished - Dec 1 2005
EventNanosensing: Materials and Devices II - Boston, MA, United States
Duration: Oct 23 2005Oct 26 2005

Keywords

  • Biosensor
  • Carbon nanotubes
  • InO nanowires
  • PSA detection

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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