Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers

Min Yue, Henry Lin, Ram Datar, Thomas Thundat, Richard J. Cote, Jeanne C. Stachowiak, Kenneth Castelino, Karolyn Hansen, Arup Chakraborty, Arun Majumdar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An array of cantilever sensors, that is capable of rapidly screening human blood samples for multiple serum tumor markers and interrogating 100 different biomolecular interactions was discussed. It was found that biomolecular interactions take place in individual microfluidic wells containing 4 to 12 cantilever sensors. The physical and chemical effects such as solvent interactions, osmotic pressure and strain energy were studied that were responsible for cantilever deflection using the immobilization of thiolated DNA on gold-coated cantilever and hybridization as a model system. The results show that the cantilever arrays were capable of multiplexed specific antibody-antigen binding detection.

Original languageEnglish (US)
Title of host publicationProceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications
PublisherAmerican Society of Mechanical Engineers
Pages27-28
Number of pages2
ISBN (Print)0791841774, 9780791841778
DOIs
StatePublished - 2004
Event3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications - Pasadena, CA, United States
Duration: Sep 22 2004Sep 24 2004

Publication series

NameProceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications

Other

Other3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications
CountryUnited States
CityPasadena, CA
Period9/22/049/24/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Yue, M., Lin, H., Datar, R., Thundat, T., Cote, R. J., Stachowiak, J. C., Castelino, K., Hansen, K., Chakraborty, A., & Majumdar, A. (2004). Nanomechanical sensor array for detection of biomolecular bindings-toward a label-free clinical assay for serum tumor markers. In Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications (pp. 27-28). [NANO2004-46034] (Proceedings of the 3rd ASME Integrated Nanosystems Conference - Design, Synthesis, and Applications). American Society of Mechanical Engineers. https://doi.org/10.1115/nano2004-46034