Nanocarriers for tracking and treating diseases

Sean Marrache, Rakesh Kumar Pathak, Kasey L. Darley, Joshua H. Choi, Dhillon Zaver, Nagesh Kolishetti, Shanta Dhar

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Site directed drug delivery with high efficacy is the biggest challenge in the area of current pharmaceuticals. Biodegradable polymer-based controlled release nanoparticle platforms could be beneficial for targeted delivery of therapeutics and contrast agents for a myriad of important human diseases. Biodegradable nanoparticles, which can be engineered to load multiple drugs with varied physicochemical properties, contrast agents, and cellular or intracellular component targeting moieties, have emerged as potential alternatives for tracking and treating human diseases. In this review, we will highlight the current advances in the design and execution of such platforms for their potential application in the diagnosis and treatment of variety of diseases ranging from cancer to Alzheimer's and we will provide a critical analysis of the associated challenges for their possible clinical translation.

Original languageEnglish (US)
Pages (from-to)3500-3514
Number of pages15
JournalCurrent medicinal chemistry
Volume20
Issue number28
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Keywords

  • Active targeting
  • Biomaterials
  • Blood-brain barrier
  • Cancer
  • Cardiovascular diseases
  • Liposome
  • Nanomedicine
  • Nanotechnology
  • Neurodegenerative diseases
  • Passive targeting
  • Polymer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Marrache, S., Pathak, R. K., Darley, K. L., Choi, J. H., Zaver, D., Kolishetti, N., & Dhar, S. (2013). Nanocarriers for tracking and treating diseases. Current medicinal chemistry, 20(28), 3500-3514. https://doi.org/10.2174/0929867311320280007