Nail changes as the first sign of systemic amyloidosis

P. A. Fanti, A. Tosti, R. Morelli, G. Galbiati

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A 68-year-old man had had for 3 years a severe onychodystrophy involving all fingers and toes which clinically mimicked nail lichen planus. The nail biopsy showed amyloid deposits in the superficial dermis of the nail matrix. Physical, pathological and laboratory examinations confirmed the diagnosis of primary systemic amyloidosis. At the time of the diagnosis the patient did not present any other cutaneous sign of systemic amyloidosis.

Original languageEnglish (US)
Pages (from-to)44-46
Number of pages3
Issue number1
StatePublished - 1991
Externally publishedYes


  • amyloid deposits
  • histopathology
  • nail changes
  • systemic amyloidosis

ASJC Scopus subject areas

  • Dermatology


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