Naftidrofuryl affects neurite regeneration by injured adult auditory neurons

Philippe P. Lefebvre, Hinrich Staecker, Gustave Moonen, Thomas R. Van de Water

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Afferent auditory neurons are essential for the transmission of auditory information from Corti's organ to the. central auditory pathway. Auditory neurons are very sensitive to acute insult and have a limited ability to regenerate injured neuronal processes. Therefore, these neurons appear to be a limiting factor in restoration of hearing function following an injury to the peripheral auditory receptor. In a previous study nerve growth factor (NGF) was shown to stimulate neurite repair but not survival of injured auditory neurons. In this study, we have demonstrated a neuritogenesis promoting effect of naftidrofuryl in an vitro model for injury to adult auditory neurons, i.e. dissociated cell cultures of adult rat spiral ganglia. Conversely, naftidrofuryl did not have any demonstrable survival promoting effect on these in vitro preparations of injured auditory neurons. The potential uses of this drug as a therapeutic agent in acute diseases of the inner ear are discussed in the light of these observations.

Original languageEnglish (US)
Pages (from-to)498-501
Number of pages4
JournalActa Oto-Laryngologica
Volume113
Issue number3
DOIs
StatePublished - Jan 1 1993

Keywords

  • Adult auditory neurons
  • Injury
  • Naftidrofuryl
  • Regeneration

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Lefebvre, P. P., Staecker, H., Moonen, G., & Van de Water, T. R. (1993). Naftidrofuryl affects neurite regeneration by injured adult auditory neurons. Acta Oto-Laryngologica, 113(3), 498-501. https://doi.org/10.3109/00016489309135852