TY - JOUR
T1 - Naftidrofuryl affects neurite regeneration by injured adult auditory neurons
AU - Lefebvre, Philippe P.
AU - Staecker, Hinrich
AU - Moonen, Gustave
AU - Van de Water, Thomas R.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Afferent auditory neurons are essential for the transmission of auditory information from Corti's organ to the. central auditory pathway. Auditory neurons are very sensitive to acute insult and have a limited ability to regenerate injured neuronal processes. Therefore, these neurons appear to be a limiting factor in restoration of hearing function following an injury to the peripheral auditory receptor. In a previous study nerve growth factor (NGF) was shown to stimulate neurite repair but not survival of injured auditory neurons. In this study, we have demonstrated a neuritogenesis promoting effect of naftidrofuryl in an vitro model for injury to adult auditory neurons, i.e. dissociated cell cultures of adult rat spiral ganglia. Conversely, naftidrofuryl did not have any demonstrable survival promoting effect on these in vitro preparations of injured auditory neurons. The potential uses of this drug as a therapeutic agent in acute diseases of the inner ear are discussed in the light of these observations.
AB - Afferent auditory neurons are essential for the transmission of auditory information from Corti's organ to the. central auditory pathway. Auditory neurons are very sensitive to acute insult and have a limited ability to regenerate injured neuronal processes. Therefore, these neurons appear to be a limiting factor in restoration of hearing function following an injury to the peripheral auditory receptor. In a previous study nerve growth factor (NGF) was shown to stimulate neurite repair but not survival of injured auditory neurons. In this study, we have demonstrated a neuritogenesis promoting effect of naftidrofuryl in an vitro model for injury to adult auditory neurons, i.e. dissociated cell cultures of adult rat spiral ganglia. Conversely, naftidrofuryl did not have any demonstrable survival promoting effect on these in vitro preparations of injured auditory neurons. The potential uses of this drug as a therapeutic agent in acute diseases of the inner ear are discussed in the light of these observations.
KW - Adult auditory neurons
KW - Injury
KW - Naftidrofuryl
KW - Regeneration
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U2 - 10.3109/00016489309135852
DO - 10.3109/00016489309135852
M3 - Article
C2 - 8379305
AN - SCOPUS:0027220035
VL - 113
SP - 498
EP - 501
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 3
ER -