TY - JOUR
T1 - N-Cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated neurons into the adult songbird brain
AU - Barami, Kaveh
AU - Kirschenbaum, Barry
AU - Lemmon, Vance
AU - Goldman, Steven A.
PY - 1994/9
Y1 - 1994/9
N2 - In the adult avian forebrain, neurons continue to be produced in the subependymal zone (SZ), from which they migrate upon radial fibers. To identify ligands regulating this process, we studied N-cadherin and Ng- CAM/8D9 expression in HVC, a neurogenic region of the canary neostriatum. N- cadherin was relatively restricted to the SZ and was expressed by dividing, [3H]thymidine-labeled precursor cells. However, cellular N-cadherin was down-regulated prior to neuronal migration from the SZ. Addition of anti-N- cadherin Fab hastened neuronal migration from adult SZ explants, without influencing neuronal number. Unlike N-cadherin, Ng-CAM/8D9 was expressed by migrating neurons. Anti-8D9 Fab inhibited neuronal migration upon cultured ependymoglia, which did not express Ng-CAM/8D9. Thus, the departure of new neurons from the adult SZ may require their suppression of N-cadherin, whereas their subsequent migration and survival may depend upon neuronal expression of Ng-CAM/8D9 and its interaction with a heterophilic radial cell receptor.
AB - In the adult avian forebrain, neurons continue to be produced in the subependymal zone (SZ), from which they migrate upon radial fibers. To identify ligands regulating this process, we studied N-cadherin and Ng- CAM/8D9 expression in HVC, a neurogenic region of the canary neostriatum. N- cadherin was relatively restricted to the SZ and was expressed by dividing, [3H]thymidine-labeled precursor cells. However, cellular N-cadherin was down-regulated prior to neuronal migration from the SZ. Addition of anti-N- cadherin Fab hastened neuronal migration from adult SZ explants, without influencing neuronal number. Unlike N-cadherin, Ng-CAM/8D9 was expressed by migrating neurons. Anti-8D9 Fab inhibited neuronal migration upon cultured ependymoglia, which did not express Ng-CAM/8D9. Thus, the departure of new neurons from the adult SZ may require their suppression of N-cadherin, whereas their subsequent migration and survival may depend upon neuronal expression of Ng-CAM/8D9 and its interaction with a heterophilic radial cell receptor.
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U2 - 10.1016/0896-6273(94)90026-4
DO - 10.1016/0896-6273(94)90026-4
M3 - Article
C2 - 7522481
AN - SCOPUS:0028109072
VL - 13
SP - 567
EP - 582
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 3
ER -