Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

P. A. Phillips, V. Sangwan, D. Borja-Cacho, V. Dudeja, S. M. Vickers, A. K. Saluja

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalCancer letters
Volume308
Issue number2
DOIs
StatePublished - Sep 28 2011

Keywords

  • Apoptosis
  • Myricetin
  • Orthotopic model
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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