Myofibroblasts: The ideal target to prevent arteriovenous fistula failure?

Juan Camilo Duque, Roberto I. Vazquez-Padron

Research output: Contribution to journalComment/debatepeer-review

9 Scopus citations


The arteriovenous fistula (AVF) failure is a major cause of morbidity in the hemodialysis population. Most AVFs fail due to neointimal hyperplasia (NIH). In this issue, Yang et al. delineated a mechanism responsible for transforming the fistula adventitia into a fertile soil for neointimal precursors. These authors pondered the role of hypoxia-regulated hypoxia-inducible factor-1 (HIF-1α), vascular endothelial growth factor A (VEGF-A), and matrix metalloproteinases (MMPs) in the activation of those adventitial myofibroblasts that may significantly contribute to the formation of the fistula neointima.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalKidney international
Issue number2
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Nephrology


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