Abstract
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a disease characterized by fibrofatty replace- ment of the right ventricular (RV) myocardium, which is generally considered to be based on variations in desmo-somal genes. However, its pathogenes is is not completely clear since myocarditis and high-intensity athletics have both been postulated to contribute to the onset and progression of the disease pattern. We observeda 21-year-old woman who presented with fulminant lymphocytic myocarditisand subsequently fulfilled the diagnostic criteria for ARVC/D by imaging and electro cardiographic characteristics after complete resolution of left ventricular(LV) abnormalities associated with myo carditis. None of the known common mutations associated with ARVC/D were identified in this patient. This report supports the hypothesis of a common pathophysiology of ARVC/D associated with desmosomal dysfunction, which can be based on genetic predisposition or acquired injury.
| Original language | English |
|---|---|
| Pages (from-to) | 1544-1548 |
| Number of pages | 5 |
| Journal | Heart Rhythm |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2013 |
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Keywords
- Arrhythmoge nicright ventricular cardiomyopathy
- Myocarditis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
Cite this
Myocarditis and ARVC/D : Variants or mimics? / Tanawuttiwat, Tanyanan; Sager, Solomon J.; Hare, Joshua; Myerburg, Robert J.
In: Heart Rhythm, Vol. 10, No. 10, 01.10.2013, p. 1544-1548.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocarditis and ARVC/D
T2 - Variants or mimics?
AU - Tanawuttiwat, Tanyanan
AU - Sager, Solomon J.
AU - Hare, Joshua
AU - Myerburg, Robert J
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a disease characterized by fibrofatty replace- ment of the right ventricular (RV) myocardium, which is generally considered to be based on variations in desmo-somal genes. However, its pathogenes is is not completely clear since myocarditis and high-intensity athletics have both been postulated to contribute to the onset and progression of the disease pattern. We observeda 21-year-old woman who presented with fulminant lymphocytic myocarditisand subsequently fulfilled the diagnostic criteria for ARVC/D by imaging and electro cardiographic characteristics after complete resolution of left ventricular(LV) abnormalities associated with myo carditis. None of the known common mutations associated with ARVC/D were identified in this patient. This report supports the hypothesis of a common pathophysiology of ARVC/D associated with desmosomal dysfunction, which can be based on genetic predisposition or acquired injury.
AB - Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a disease characterized by fibrofatty replace- ment of the right ventricular (RV) myocardium, which is generally considered to be based on variations in desmo-somal genes. However, its pathogenes is is not completely clear since myocarditis and high-intensity athletics have both been postulated to contribute to the onset and progression of the disease pattern. We observeda 21-year-old woman who presented with fulminant lymphocytic myocarditisand subsequently fulfilled the diagnostic criteria for ARVC/D by imaging and electro cardiographic characteristics after complete resolution of left ventricular(LV) abnormalities associated with myo carditis. None of the known common mutations associated with ARVC/D were identified in this patient. This report supports the hypothesis of a common pathophysiology of ARVC/D associated with desmosomal dysfunction, which can be based on genetic predisposition or acquired injury.
KW - Arrhythmoge nicright ventricular cardiomyopathy
KW - Myocarditis
UR - http://www.scopus.com/inward/record.url?scp=84884672688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884672688&partnerID=8YFLogxK
U2 - 10.1016/j.hrthm.2013.06.008
DO - 10.1016/j.hrthm.2013.06.008
M3 - Article
C2 - 23773988
AN - SCOPUS:84884672688
VL - 10
SP - 1544
EP - 1548
JO - Heart Rhythm
JF - Heart Rhythm
SN - 1547-5271
IS - 10
ER -