Myocarditis and ARVC/D: Variants or mimics?

Tanyanan Tanawuttiwat, Solomon J. Sager, Joshua M. Hare, Robert J. Myerburg

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a disease characterized by fibrofatty replace- ment of the right ventricular (RV) myocardium, which is generally considered to be based on variations in desmo-somal genes. However, its pathogenes is is not completely clear since myocarditis and high-intensity athletics have both been postulated to contribute to the onset and progression of the disease pattern. We observeda 21-year-old woman who presented with fulminant lymphocytic myocarditisand subsequently fulfilled the diagnostic criteria for ARVC/D by imaging and electro cardiographic characteristics after complete resolution of left ventricular(LV) abnormalities associated with myo carditis. None of the known common mutations associated with ARVC/D were identified in this patient. This report supports the hypothesis of a common pathophysiology of ARVC/D associated with desmosomal dysfunction, which can be based on genetic predisposition or acquired injury.

Original languageEnglish (US)
Pages (from-to)1544-1548
Number of pages5
JournalHeart rhythm
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2013

Keywords

  • Arrhythmoge nicright ventricular cardiomyopathy
  • Myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Myocarditis and ARVC/D: Variants or mimics?'. Together they form a unique fingerprint.

  • Cite this