Myocardial protection in the hypertrophied right ventricle

Robert James Cusimano, Kassem A. Ashe, Ian D. Chin, Peter Chi, James G. Abel, Samuel V. Lichtenstein, Tomas A. Salerno

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Hypertrophied right ventricle presents a sensitive state that may not be adequately protected by modern cardioplegic methods. Cardiac metabolism, performance, and ultrastructure were measured in response to 1 hour of cardioplegic arrest in 15 pigs with right ventricular hypertrophy using intermittent hypothermic crystalloid, blood, and Fluosol DA 20%-based cardioplegia. Reperfusion time was 1 hour. One hour after a 60-minute cross-clamp period, there were no differences in light microscopy. Total energy stores increased in 4 of 5 animals given blood cardioplegia compared with 1 of 5 for each of the other groups. Cardiac performance data also showed better results for animals treated with blood cardioplegia. After 30 minutes of reperfusion, animals receiving blood cardioplegia recovered 131% ± 42% of preoperative systolic performance compared with 106% ± 49% for Fluosol-treated animals and only 82% ± 27% recovery for the crystalloid-treated group. After 60 minutes of reperfusion, the blood group showed 119% ± 20% recovery compared with 89% ± 23% and 85% ± 50% recovery for Fluosol- and crystalloid-treated hearts, respectively. In conclusion, blood cardioplegia provided better protection than did crystalloid or Fluosol DA 20% cardioplegia when animals with right ventricular hypertrophy underwent 1 hour of cardioplegic arrest. It may have repaired damaged myocardium, leaving better hearts after cross-clamping than before.

Original languageEnglish (US)
Pages (from-to)934-938
Number of pages5
JournalThe Annals of Thoracic Surgery
Issue number4
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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