TY - JOUR
T1 - Myocardial protection in the hypertrophied right ventricle
AU - Cusimano, Robert James
AU - Ashe, Kassem A.
AU - Chin, Ian D.
AU - Chi, Peter
AU - Abel, James G.
AU - Lichtenstein, Samuel V.
AU - Salerno, Tomas A.
PY - 1991/10
Y1 - 1991/10
N2 - Hypertrophied right ventricle presents a sensitive state that may not be adequately protected by modern cardioplegic methods. Cardiac metabolism, performance, and ultrastructure were measured in response to 1 hour of cardioplegic arrest in 15 pigs with right ventricular hypertrophy using intermittent hypothermic crystalloid, blood, and Fluosol DA 20%-based cardioplegia. Reperfusion time was 1 hour. One hour after a 60-minute cross-clamp period, there were no differences in light microscopy. Total energy stores increased in 4 of 5 animals given blood cardioplegia compared with 1 of 5 for each of the other groups. Cardiac performance data also showed better results for animals treated with blood cardioplegia. After 30 minutes of reperfusion, animals receiving blood cardioplegia recovered 131% ± 42% of preoperative systolic performance compared with 106% ± 49% for Fluosol-treated animals and only 82% ± 27% recovery for the crystalloid-treated group. After 60 minutes of reperfusion, the blood group showed 119% ± 20% recovery compared with 89% ± 23% and 85% ± 50% recovery for Fluosol- and crystalloid-treated hearts, respectively. In conclusion, blood cardioplegia provided better protection than did crystalloid or Fluosol DA 20% cardioplegia when animals with right ventricular hypertrophy underwent 1 hour of cardioplegic arrest. It may have repaired damaged myocardium, leaving better hearts after cross-clamping than before.
AB - Hypertrophied right ventricle presents a sensitive state that may not be adequately protected by modern cardioplegic methods. Cardiac metabolism, performance, and ultrastructure were measured in response to 1 hour of cardioplegic arrest in 15 pigs with right ventricular hypertrophy using intermittent hypothermic crystalloid, blood, and Fluosol DA 20%-based cardioplegia. Reperfusion time was 1 hour. One hour after a 60-minute cross-clamp period, there were no differences in light microscopy. Total energy stores increased in 4 of 5 animals given blood cardioplegia compared with 1 of 5 for each of the other groups. Cardiac performance data also showed better results for animals treated with blood cardioplegia. After 30 minutes of reperfusion, animals receiving blood cardioplegia recovered 131% ± 42% of preoperative systolic performance compared with 106% ± 49% for Fluosol-treated animals and only 82% ± 27% recovery for the crystalloid-treated group. After 60 minutes of reperfusion, the blood group showed 119% ± 20% recovery compared with 89% ± 23% and 85% ± 50% recovery for Fluosol- and crystalloid-treated hearts, respectively. In conclusion, blood cardioplegia provided better protection than did crystalloid or Fluosol DA 20% cardioplegia when animals with right ventricular hypertrophy underwent 1 hour of cardioplegic arrest. It may have repaired damaged myocardium, leaving better hearts after cross-clamping than before.
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U2 - 10.1016/0003-4975(91)91258-W
DO - 10.1016/0003-4975(91)91258-W
M3 - Article
C2 - 1834034
AN - SCOPUS:0025992574
VL - 52
SP - 934
EP - 938
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 4
ER -