Myocardial protection during coronary angioplasty with an autoperfusion balloon catheter in humans

P. J. Quigley, T. Hinohara, H. R. Phillips, R. H. Peter, V. S. Behar, Y. Kong, C. A. Simonton, J. A. Perez, R. S. Stack

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during inflation through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. We report its safety and efficacy in 11 patients undergoing elective angioplasty to a single coronary lesion. Each lesion was dilated three times with the autoperfusion inflation bracketed between two inflations by standard angioplasty catheters. Chest pain score, 12-lead electrocardiogram, heart rate, and mean aortic pressure were recorded before each inflation and at 1-minute intervals after inflation. Inflation duration during autoperfusion angioplasty (513 ± 303 seconds) was longer than for the pre- (107 ± 55 seconds, p = 0.0004) and post-(139 ± 71 seconds, p = 0.0006) standard dilatations. The maximum ST-segment elevation and depression in any lead during autoperfusion angioplasty (0.3 ± 0.5 and 0.6 ± 0.8 mm) was significantly less than for the pre- (2.4 ± 1.7 mm, p = 0.002 and 2.2 ± 1.3 mm, p = 0.0004) or post- (1.9 ±1.3 mm, p = 0.002 and 1.6 ± 1.3 mm, p = 0.018) standard dilatations at the same point in time. Maximal chest pain score during autoperfusion (3.2 ± 3.5) was lower than for the pre- (6.1 ± 2.1, p = 0.003) but not the post- (5.2 ± 3.1, p = 0.07) standard angioplasty. All 11 patients underwent successful, uncomplicated procedures. We conclude that this autoperfusion catheter significantly reduces ischemic symptoms and signs during coronary angioplasty, allowing prolonged periods of balloon inflation.

Original languageEnglish (US)
Pages (from-to)1128-1134
Number of pages7
Issue number5 I
StatePublished - 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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