Abstract
An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during inflation through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. We report its safety and efficacy in 11 patients undergoing elective angioplasty to a single coronary lesion. Each lesion was dilated three times with the autoperfusion inflation bracketed between two inflations by standard angioplasty catheters. Chest pain score, 12-lead electrocardiogram, heart rate, and mean aortic pressure were recorded before each inflation and at 1-minute intervals after inflation. Inflation duration during autoperfusion angioplasty (513 ± 303 seconds) was longer than for the pre- (107 ± 55 seconds, p = 0.0004) and post-(139 ± 71 seconds, p = 0.0006) standard dilatations. The maximum ST-segment elevation and depression in any lead during autoperfusion angioplasty (0.3 ± 0.5 and 0.6 ± 0.8 mm) was significantly less than for the pre- (2.4 ± 1.7 mm, p = 0.002 and 2.2 ± 1.3 mm, p = 0.0004) or post- (1.9 ±1.3 mm, p = 0.002 and 1.6 ± 1.3 mm, p = 0.018) standard dilatations at the same point in time. Maximal chest pain score during autoperfusion (3.2 ± 3.5) was lower than for the pre- (6.1 ± 2.1, p = 0.003) but not the post- (5.2 ± 3.1, p = 0.07) standard angioplasty. All 11 patients underwent successful, uncomplicated procedures. We conclude that this autoperfusion catheter significantly reduces ischemic symptoms and signs during coronary angioplasty, allowing prolonged periods of balloon inflation.
| Original language | English |
|---|---|
| Pages (from-to) | 1128-1134 |
| Number of pages | 7 |
| Journal | Circulation |
| Volume | 78 |
| Issue number | 5 I |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Myocardial protection during coronary angioplasty with an autoperfusion balloon catheter in humans. / Quigley, P. J.; Hinohara, T.; Phillips, H. R.; Peter, R. H.; Behar, V. S.; Kong, Y.; Simonton, C. A.; Perez, J. A.; Stack, R. S.
In: Circulation, Vol. 78, No. 5 I, 01.01.1988, p. 1128-1134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial protection during coronary angioplasty with an autoperfusion balloon catheter in humans
AU - Quigley, P. J.
AU - Hinohara, T.
AU - Phillips, H. R.
AU - Peter, R. H.
AU - Behar, V. S.
AU - Kong, Y.
AU - Simonton, C. A.
AU - Perez, J. A.
AU - Stack, R. S.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during inflation through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. We report its safety and efficacy in 11 patients undergoing elective angioplasty to a single coronary lesion. Each lesion was dilated three times with the autoperfusion inflation bracketed between two inflations by standard angioplasty catheters. Chest pain score, 12-lead electrocardiogram, heart rate, and mean aortic pressure were recorded before each inflation and at 1-minute intervals after inflation. Inflation duration during autoperfusion angioplasty (513 ± 303 seconds) was longer than for the pre- (107 ± 55 seconds, p = 0.0004) and post-(139 ± 71 seconds, p = 0.0006) standard dilatations. The maximum ST-segment elevation and depression in any lead during autoperfusion angioplasty (0.3 ± 0.5 and 0.6 ± 0.8 mm) was significantly less than for the pre- (2.4 ± 1.7 mm, p = 0.002 and 2.2 ± 1.3 mm, p = 0.0004) or post- (1.9 ±1.3 mm, p = 0.002 and 1.6 ± 1.3 mm, p = 0.018) standard dilatations at the same point in time. Maximal chest pain score during autoperfusion (3.2 ± 3.5) was lower than for the pre- (6.1 ± 2.1, p = 0.003) but not the post- (5.2 ± 3.1, p = 0.07) standard angioplasty. All 11 patients underwent successful, uncomplicated procedures. We conclude that this autoperfusion catheter significantly reduces ischemic symptoms and signs during coronary angioplasty, allowing prolonged periods of balloon inflation.
AB - An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during inflation through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. We report its safety and efficacy in 11 patients undergoing elective angioplasty to a single coronary lesion. Each lesion was dilated three times with the autoperfusion inflation bracketed between two inflations by standard angioplasty catheters. Chest pain score, 12-lead electrocardiogram, heart rate, and mean aortic pressure were recorded before each inflation and at 1-minute intervals after inflation. Inflation duration during autoperfusion angioplasty (513 ± 303 seconds) was longer than for the pre- (107 ± 55 seconds, p = 0.0004) and post-(139 ± 71 seconds, p = 0.0006) standard dilatations. The maximum ST-segment elevation and depression in any lead during autoperfusion angioplasty (0.3 ± 0.5 and 0.6 ± 0.8 mm) was significantly less than for the pre- (2.4 ± 1.7 mm, p = 0.002 and 2.2 ± 1.3 mm, p = 0.0004) or post- (1.9 ±1.3 mm, p = 0.002 and 1.6 ± 1.3 mm, p = 0.018) standard dilatations at the same point in time. Maximal chest pain score during autoperfusion (3.2 ± 3.5) was lower than for the pre- (6.1 ± 2.1, p = 0.003) but not the post- (5.2 ± 3.1, p = 0.07) standard angioplasty. All 11 patients underwent successful, uncomplicated procedures. We conclude that this autoperfusion catheter significantly reduces ischemic symptoms and signs during coronary angioplasty, allowing prolonged periods of balloon inflation.
UR - http://www.scopus.com/inward/record.url?scp=0023701661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023701661&partnerID=8YFLogxK
M3 - Article
C2 - 2972418
AN - SCOPUS:0023701661
VL - 78
SP - 1128
EP - 1134
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 5 I
ER -