Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin i in cynomolgus monkeys

Michael E. Dunn, Denise Coluccio, Tanja S. Zabka, Gopakumar Gopalakrishnan, Gerard Hirkaler, Wanping Geng, Rosemary Nicklaus, Steven E. Lipshultz, Lucette Doessegger, Brett H. Saladino, Thomas Singer, Igor Mikaelian

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Myocardial mononuclear cell infiltrate is a spontaneous cardiac finding commonly identified in laboratory cynomolgus monkeys. The infiltrates are predominantly composed of macrophages with lesser lymphocytes and are not typically associated with histologically detectable cardiomyocyte degeneration. These infiltrates are of concern because they confound interpretation of test article-related histopathology findings in nonclinical safety toxicology studies. The interpretation of safety studies would be simplified by a biomarker that could identify myocardial infiltrates prior to animal placement on study. We hypothesized that monkeys with myocardial mononuclear cell infiltrates could be identified before necropsy using an ultrasensitive immunoassay for cardiac troponin I (cTnI). Serum cTnI concentrations in monkeys with myocardial infiltrates were not higher than those in monkeys without infiltrates at any of the sampling times before and on the day of necropsy. Increased serum cTnI levels are not suitable for screening monkeys with myocardial mononuclear cell infiltrates before placement in the study.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalToxicologic Pathology
Volume40
Issue number4
DOIs
StatePublished - Jun 1 2012

Keywords

  • biomarker
  • cardiac troponin I
  • heart
  • infiltrate
  • monkey
  • myocardial inflammation
  • spontaneous background disease
  • ultrasensitive assay

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin i in cynomolgus monkeys'. Together they form a unique fingerprint.

  • Cite this

    Dunn, M. E., Coluccio, D., Zabka, T. S., Gopalakrishnan, G., Hirkaler, G., Geng, W., Nicklaus, R., Lipshultz, S. E., Doessegger, L., Saladino, B. H., Singer, T., & Mikaelian, I. (2012). Myocardial mononuclear cell infiltrates are not associated with increased serum cardiac troponin i in cynomolgus monkeys. Toxicologic Pathology, 40(4), 647-650. https://doi.org/10.1177/0192623311436176