Myocardial infarction scar plication in the rat: Cardiac mechanics in an animal model for surgical procedures

Rosemeire Takeuchi, Emília Nozawa, Neif Murad, Luis R. Gerola, Valdir A. Moisés, Paulo J F Tucci

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. The immediate effects of surgical reduction of left ventricle cavity on cardiac mechanics have not been well defined. Methods. Cardiac mechanics were analyzed before and after myocardial infarction scar plication in 11 isolated infarcted rat hearts. Results. Despite a decrease in myocardial stiffness, an increase in chamber stiffness was noted after myocardial infarction scar plication. Systolic function was favored in more than one way. For the same diastolic pressures, maximal developed pressures were higher after myocardial infarction scar plication, and the slope of the systolic pressure-volume relationship was steeper afterwards as compared with before; this means that Frank-Starling recruitment is accentuated in smaller cavities. In addition, the developed net forces needed to generate these pressures were clearly lower afterward than before, indicating reduced ventricular afterload. Conclusions. The study results show that diastolic function is harmed and systolic function is favored by myocardial infarction scar plication. We suggest that preoperative evaluation of the degree of diastolic dysfunction and impairment of the Frank-Starling mechanism may help to identify patients who may have a poor postoperative outcome due to diastolic or systolic dysfunction.

Original languageEnglish (US)
Pages (from-to)1507-1513
Number of pages7
JournalAnnals of Thoracic Surgery
Volume73
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

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Mechanics
Cicatrix
Animal Models
Myocardial Infarction
Starlings
Blood Pressure
Pressure
Heart Ventricles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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Myocardial infarction scar plication in the rat : Cardiac mechanics in an animal model for surgical procedures. / Takeuchi, Rosemeire; Nozawa, Emília; Murad, Neif; Gerola, Luis R.; Moisés, Valdir A.; Tucci, Paulo J F.

In: Annals of Thoracic Surgery, Vol. 73, No. 5, 2002, p. 1507-1513.

Research output: Contribution to journalArticle

Takeuchi, Rosemeire ; Nozawa, Emília ; Murad, Neif ; Gerola, Luis R. ; Moisés, Valdir A. ; Tucci, Paulo J F. / Myocardial infarction scar plication in the rat : Cardiac mechanics in an animal model for surgical procedures. In: Annals of Thoracic Surgery. 2002 ; Vol. 73, No. 5. pp. 1507-1513.
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