Myocardial biochemical and hemodynamic adaptations to chronic tachycardia

C. D. Ianuzzo, S. Brotherton, P. O'Brien, Tomas Salerno, M. H. Laughlin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose was to determine the biochemical and hemodynamic adaptations of the myocardium to chronic tachycardia. Cardiac pacemakers were implanted in Yorkshire pigs and set at a rate of 180 beats/min for a period of 35-42 days. Animals were then anesthetized with pentobarbital sodium. Myocardial blood flow and hemodynamics were determined at three different heart rates (i.e., 120, 180, and 220 beats/min). Tissue samples were then taken for microsphere and biochemical analyses. Chronically paced hearts maintained better cardiac function and had consistently higher left ventricular blood flow with a higher endocardial-to-epicardial ratio. The activities of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase were 23 and 45% greater in the paced hearts, respectively. The sarcoplasmic reticulum adenosinetriphosphatase activity was 55% greater in the paced hearts, whereas the myosin adenosinetriphosphatase was the same as in the control hearts. Polyacrylamide gels of the ventricular myosin isoforms showed only the V3 type to be present in both the control and paced hearts. These findings show that the heart of a large mammal adapts to chronic tachycardia (i.e., 180 beats/ min) by elevating the aerobic and calcium-sequestering capacities without altering its myosin type.

Original languageEnglish
Pages (from-to)907-913
Number of pages7
JournalJournal of Applied Physiology
Volume70
Issue number2
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Tachycardia
Hemodynamics
Myosins
3-Hydroxyacyl-CoA Dehydrogenase
Ventricular Myosins
Citrate (si)-Synthase
Sarcoplasmic Reticulum
Pentobarbital
Microspheres
Adenosine Triphosphatases
Mammals
Myocardium
Protein Isoforms
Swine
Heart Rate
Calcium

Keywords

  • biochemical adaptive strategies
  • metabolic capacities
  • myocardial blood flow
  • myosin isoforms
  • sarcoplasmic reticulum
  • Yorkshire pigs

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Ianuzzo, C. D., Brotherton, S., O'Brien, P., Salerno, T., & Laughlin, M. H. (1991). Myocardial biochemical and hemodynamic adaptations to chronic tachycardia. Journal of Applied Physiology, 70(2), 907-913.

Myocardial biochemical and hemodynamic adaptations to chronic tachycardia. / Ianuzzo, C. D.; Brotherton, S.; O'Brien, P.; Salerno, Tomas; Laughlin, M. H.

In: Journal of Applied Physiology, Vol. 70, No. 2, 01.01.1991, p. 907-913.

Research output: Contribution to journalArticle

Ianuzzo, CD, Brotherton, S, O'Brien, P, Salerno, T & Laughlin, MH 1991, 'Myocardial biochemical and hemodynamic adaptations to chronic tachycardia', Journal of Applied Physiology, vol. 70, no. 2, pp. 907-913.
Ianuzzo CD, Brotherton S, O'Brien P, Salerno T, Laughlin MH. Myocardial biochemical and hemodynamic adaptations to chronic tachycardia. Journal of Applied Physiology. 1991 Jan 1;70(2):907-913.
Ianuzzo, C. D. ; Brotherton, S. ; O'Brien, P. ; Salerno, Tomas ; Laughlin, M. H. / Myocardial biochemical and hemodynamic adaptations to chronic tachycardia. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 2. pp. 907-913.
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