Myocardial alterations associated with aortocoronary saphenous vein bypass

M. J. Robinson, R. Lam, Azorides R Morales

Research output: Contribution to journalArticle

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Abstract

Clinical observations and gross and microscopic morphology of the hearts of 50 patients who died at various intervals following aortocoronary saphenous vein bypass procedures are presented. Time of total cardiopulmonary bypass varied inversely with survival time among these patients. Myocardial necrosis with contraction bands and/or hemorrhagic myocardial necrosis was observed in the hearts of 44 of the 50 patients. Pathogenesis of the acute myocardial necrosis with contraction bands was multifactorial: anoxic arrest, cardiotonic drugs, electrical defibrillation, electrolyte imbalance, microthrombi, and hypoperfusion are incriminated. Subendocardial hemorrhagic necrosis was present in 17 of 40 patients whose postoperative survivals were 4 days or less. Its frequency increased with duration of survival. Hypoperfusion of the myocardium is suggested as the major etiologic factor of the subendocardial hemorrhagic necrosis. Myocardial lesions observed among these 50 patients did not differ from those in patients who had open heart surgery for other reasons.

Original languageEnglish
Pages (from-to)721-728
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume68
Issue number6
StatePublished - Dec 1 1977

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Saphenous Vein
Necrosis
Survival
Cardiotonic Agents
Cardiopulmonary Bypass
Electrolytes
Thoracic Surgery
Myocardium

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Myocardial alterations associated with aortocoronary saphenous vein bypass. / Robinson, M. J.; Lam, R.; Morales, Azorides R.

In: American Journal of Clinical Pathology, Vol. 68, No. 6, 01.12.1977, p. 721-728.

Research output: Contribution to journalArticle

Robinson, MJ, Lam, R & Morales, AR 1977, 'Myocardial alterations associated with aortocoronary saphenous vein bypass', American Journal of Clinical Pathology, vol. 68, no. 6, pp. 721-728.
Robinson, M. J. ; Lam, R. ; Morales, Azorides R. / Myocardial alterations associated with aortocoronary saphenous vein bypass. In: American Journal of Clinical Pathology. 1977 ; Vol. 68, No. 6. pp. 721-728.
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