Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study

M. Larramendy; W. El-Rifai; U. Saarinen; R. Alitalo; S. Luomahaara; S. Knuutila

Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study

M. Larramendy, W. El-Rifai, U. Saarinen, R. Alitalo, S. Luomahaara, S. Knuutila

Research output: Contribution to journal › Article › peer-review

Abstract

We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22⁺ and CD3⁺ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10⁺ and CD19⁺ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.

Original language	English (US)
Pages (from-to)	1563-1567
Number of pages	5
Journal	Experimental Hematology
Volume	23
Issue number	14
State	Published - Dec 1 1995
Externally published	Yes

Keywords

ALL
Erythrocyte lineage
MAC methodology
Myeloid lineage

ASJC Scopus subject areas

Molecular Biology
Hematology
Genetics
Cell Biology
Cancer Research

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title = "Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study",

abstract = "We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.",

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T1 - Myeloid lineage involvement in acute lymphoblastic leukemia

T2 - A morphology antibody chromosomes (MAC) study

AU - Larramendy, M.

AU - El-Rifai, W.

AU - Saarinen, U.

AU - Alitalo, R.

AU - Luomahaara, S.

AU - Knuutila, S.

PY - 1995/12/1

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AB - We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.

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