Abstract
We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1563-1567 |
| Number of pages | 5 |
| Journal | Experimental Hematology |
| Volume | 23 |
| Issue number | 14 |
| State | Published - Dec 1 1995 |
| Externally published | Yes |
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Keywords
- ALL
- Erythrocyte lineage
- MAC methodology
- Myeloid lineage
ASJC Scopus subject areas
- Molecular Biology
- Hematology
- Genetics
- Cell Biology
- Cancer Research
Cite this
Myeloid lineage involvement in acute lymphoblastic leukemia : A morphology antibody chromosomes (MAC) study. / Larramendy, M.; El-Rifai, Wael; Saarinen, U.; Alitalo, R.; Luomahaara, S.; Knuutila, S.
In: Experimental Hematology, Vol. 23, No. 14, 01.12.1995, p. 1563-1567.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myeloid lineage involvement in acute lymphoblastic leukemia
T2 - A morphology antibody chromosomes (MAC) study
AU - Larramendy, M.
AU - El-Rifai, Wael
AU - Saarinen, U.
AU - Alitalo, R.
AU - Luomahaara, S.
AU - Knuutila, S.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.
AB - We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.
KW - ALL
KW - Erythrocyte lineage
KW - MAC methodology
KW - Myeloid lineage
UR - http://www.scopus.com/inward/record.url?scp=0029558782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029558782&partnerID=8YFLogxK
M3 - Article
C2 - 8542947
AN - SCOPUS:0029558782
VL - 23
SP - 1563
EP - 1567
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 14
ER -