Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study

M. Larramendy, W. El-Rifai, U. Saarinen, R. Alitalo, S. Luomahaara, S. Knuutila

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.

Original languageEnglish (US)
Pages (from-to)1563-1567
Number of pages5
JournalExperimental Hematology
Volume23
Issue number14
StatePublished - Dec 1 1995
Externally publishedYes

Keywords

  • ALL
  • Erythrocyte lineage
  • MAC methodology
  • Myeloid lineage

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study'. Together they form a unique fingerprint.

  • Cite this

    Larramendy, M., El-Rifai, W., Saarinen, U., Alitalo, R., Luomahaara, S., & Knuutila, S. (1995). Myeloid lineage involvement in acute lymphoblastic leukemia: A morphology antibody chromosomes (MAC) study. Experimental Hematology, 23(14), 1563-1567.