Myeloid derived suppressor cells in physiological and pathological conditions: The good, the bad, and the ugly

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71 Scopus citations

Abstract

Myeloid derived suppressor cells (MDSCs), a heterogeneous population of myeloid progenitors, are recognized as a key element in tumor escape and progression the importance of MDSCs in human malignancies has been demonstrated in recent years, and new approaches targeting their suppressive/tolerogenic action are currently being tested in both preclinical model and clinical trials. However, emerging evidence suggests that MDSCs may play a prominent role as regulator of the physiologic, the chronic, and the pathologic immune responses. This review will focus on the biology of MDSC in light of these new findings and the possible role of this myeloid population not only in the progression of the tumor but also in its initiation.

Original languageEnglish (US)
Pages (from-to)172-184
Number of pages13
JournalImmunologic Research
Volume57
Issue number1-3
DOIs
StatePublished - Dec 1 2013

Keywords

  • Carcinogenesis
  • Chronic inflammation
  • MDSCs subsets
  • Myeloid derived suppressor cells
  • Physiological immune response
  • Tumor progression

ASJC Scopus subject areas

  • Immunology

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