Myelodysplasia associated with Turner syndrome

L. Allison Foster, Miguel R. Abboud, Ashby B. Taylor, Julio Barredo, John Lazarchick, Joseph Laver

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: This study reports the association of myelodysplasia with Turner syndrome. Patient and Methods: An 11-year-old girl with Turner syndrome was found to have mild macrocytic anemia that persisted during 2 years. Results: Examination of the bone marrow revealed dyserythropoietic features with multinucleation consistent with refractory anemia. Levels of hemoglobin F were also markedly elevated (57%). She also had transient neutropenia and thrombocytopenia, as well as abnormal platelet function studies. The hematopoietic abnormalities were mild and may have been missed were she not followed for her hypertension and aortic coarctation. Conclusions: Myelodysplastic syndromes in children are frequently associated with chromosomal abnormalities, but an association with Turner syndrome has not been previously described. This could be due to the fact that mild hematopoietic abnormalities in these patients may not be investigated.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Issue number3
StatePublished - Aug 10 1996
Externally publishedYes


  • Hemoglobin F
  • Myelodysplastic syndromes
  • Refractory anemia
  • Turner syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology


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