Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis

Mohsen Heidary, Mohammad Javad Nasiri, Mehdi Mirsaeidi, Faramarz Masjedian Jazi, Saeed Khoshnood, Michel Drancourt, Davood Darban-Sarokhalil

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV. Methods: Embase, PubMed, and Web of Science were searched for relevant studies. All statistical analyses were performed by STATA version 14. Results: From 6,627 retrieved articles, 23 were included in the final analysis. A total of 18,463 patients with HIV were included in the analysis. The frequency of MAC infection in patients with HIV was found to be 10.6% (95% confidence interval, 6.9–14.2). Conclusion: The relatively large fractions of HIV-infected patients were coinfected with MAC, which may poses significant public health problems. Continued progress in the development of rapid diagnostic methods and preventive therapy for MAC should lead to further improvements in survival and quality of life in patients with HIV.

Original languageEnglish (US)
Pages (from-to)9994-10001
Number of pages8
JournalJournal of Cellular Physiology
Volume234
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • AIDS
  • HIV
  • Mycobacterium avium complex
  • meta-analysis

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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