Mycobacterium abscessus infection in solid organ transplant recipients: Report of three cases and review of the literature: Case report

A. P. Garrison, Michele I Morris, Susanne Doblecki-Lewis, Lesley J Smith, Timothy Cleary, G. W. Procop, V. Vincek, Isabella Rosa-Cunha, B. Alfonso, George W Burke, A. Tzakis, A. I. Hartstein

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mycobacterium abscessus is an ubiquitous organism found in the environment. This rapidly growing mycobacterium infrequently causes disease in humans; however, in immunocompromised hosts, disease can range from localized cutaneous lesions to disseminated infection. The organism is resistant to most antimycobacterial drugs and therapy can be limited by drug interactions. The exact incidence of M. abscessus infection among solid organ transplant (SOT) recipients is unknown; data are only available from previously reported cases in the literature. We describe 3 cases of M. abscessus infection in SOT recipients diagnosed within a 5-month period. One of the cases followed multi-visceral transplantation, the first such case to be reported in the literature. An epidemiological investigation did not reveal significant commonalities among the cases, and pulsed-field gel electrophoresis of genomic DNA of the case isolates confirmed their non-identity. All cases improved with antibiotic therapy, most notably with the new glycylcycline, tigecycline, along with surgical intervention in 2 of the cases. In addition, we review features and characteristics of M. abscessus infections in recipients of SOT reported in the literature from 1992 to 2008 and summarize some selected therapeutic concerns and issues related to treatment.

Original languageEnglish
Pages (from-to)541-548
Number of pages8
JournalTransplant Infectious Disease
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2009

Fingerprint

Mycobacterium Infections
Transplants
Mycobacterium
Infection
Pulsed Field Gel Electrophoresis
Immunocompromised Host
Drug Interactions
Therapeutics
Transplantation
Anti-Bacterial Agents
Drug Therapy
Skin
Transplant Recipients
DNA
Incidence

Keywords

  • Drug interactions
  • Immunosuppression
  • Mycobacterium abscessus
  • Tigecycline
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Mycobacterium abscessus infection in solid organ transplant recipients : Report of three cases and review of the literature: Case report. / Garrison, A. P.; Morris, Michele I; Doblecki-Lewis, Susanne; Smith, Lesley J; Cleary, Timothy; Procop, G. W.; Vincek, V.; Rosa-Cunha, Isabella; Alfonso, B.; Burke, George W; Tzakis, A.; Hartstein, A. I.

In: Transplant Infectious Disease, Vol. 11, No. 6, 01.12.2009, p. 541-548.

Research output: Contribution to journalArticle

Garrison, A. P. ; Morris, Michele I ; Doblecki-Lewis, Susanne ; Smith, Lesley J ; Cleary, Timothy ; Procop, G. W. ; Vincek, V. ; Rosa-Cunha, Isabella ; Alfonso, B. ; Burke, George W ; Tzakis, A. ; Hartstein, A. I. / Mycobacterium abscessus infection in solid organ transplant recipients : Report of three cases and review of the literature: Case report. In: Transplant Infectious Disease. 2009 ; Vol. 11, No. 6. pp. 541-548.
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