Mycobacterium abscessus infection in cystic fibrosis: Colonization or infection?

Anne R. Cullen, Carolyn L. Cannon, Eugene J. Mark, Andrew Colin

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We present a case of a patient with cystic fibrosis who was thought to be colonized with Mycobacterium abscessus for 13 yr prior to developing clinically apparent mycobacterial infection. However, histologic evidence indicated that invasive mycobacterial disease was present from the onset. While accepting that chronic endobronchial colonization with atypical mycobacteria may occur in patients with cystic fibrosis, the repeated isolation of mycobacteria from the sputum of these patients should alert the clinician to the possibility of indolent disease. Early consideration of treatment for this infection should occur in any patient with cystic fibrosis in whom there is an unexplained deterioration in lung function. The recent introduction of high dose ibuprofen raises concerns about its possible contribution to the progression of the infection.

Original languageEnglish
Pages (from-to)641-645
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume161
Issue number2 I
StatePublished - Mar 14 2000
Externally publishedYes

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Mycobacterium Infections
Cystic Fibrosis
Mycobacterium
Infection
Nontuberculous Mycobacteria
Ibuprofen
Sputum
Lung
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mycobacterium abscessus infection in cystic fibrosis : Colonization or infection? / Cullen, Anne R.; Cannon, Carolyn L.; Mark, Eugene J.; Colin, Andrew.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 161, No. 2 I, 14.03.2000, p. 641-645.

Research output: Contribution to journalArticle

Cullen, Anne R. ; Cannon, Carolyn L. ; Mark, Eugene J. ; Colin, Andrew. / Mycobacterium abscessus infection in cystic fibrosis : Colonization or infection?. In: American Journal of Respiratory and Critical Care Medicine. 2000 ; Vol. 161, No. 2 I. pp. 641-645.
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