Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia

Thomas Pabst, Erica Stillner, Donna Neuberg, Stephen D Nimer, Cheryl L. Willman, Alan F. List, Junia V. Melo, Daniel G. Tenen, Beatrice U. Mueller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The transcription factor CEBPA is crucial for normal myeloid differentiation. CEBPA gene mutations have been reported in patients with acute myeloid leukaemia. The inevitable evolution of chronic myeloid leukaemia (CML) in chronic phase (CP) to a fatal blast crisis (BC) is assumed to result from the acquisition of additional genetic changes in the leukaemic clone. Gain of CEBPA mutations might represent a key event causing the differentiation block observed in myeloid CML-BC, but not in CML-CP. Here, no CEBPA mutation in 95 CML-BC patients was found, suggesting a limited role, if any, of CEBPA mutations in this disorder.

Original languageEnglish
Pages (from-to)400-402
Number of pages3
JournalBritish Journal of Haematology
Volume133
Issue number4
DOIs
StatePublished - May 1 2006
Externally publishedYes

Fingerprint

Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Transcription Factors
Leukemia, Myeloid, Chronic Phase
Mutation
Acute Myeloid Leukemia
Clone Cells
Genes

Keywords

  • CEBPA
  • Chronic myeloid leukaemia
  • Differentiation
  • Mutation
  • Transcription factor

ASJC Scopus subject areas

  • Hematology

Cite this

Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia. / Pabst, Thomas; Stillner, Erica; Neuberg, Donna; Nimer, Stephen D; Willman, Cheryl L.; List, Alan F.; Melo, Junia V.; Tenen, Daniel G.; Mueller, Beatrice U.

In: British Journal of Haematology, Vol. 133, No. 4, 01.05.2006, p. 400-402.

Research output: Contribution to journalArticle

Pabst, Thomas ; Stillner, Erica ; Neuberg, Donna ; Nimer, Stephen D ; Willman, Cheryl L. ; List, Alan F. ; Melo, Junia V. ; Tenen, Daniel G. ; Mueller, Beatrice U. / Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia. In: British Journal of Haematology. 2006 ; Vol. 133, No. 4. pp. 400-402.
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