Mutations in the p53 tumor suppressor gene and early onset breast cancer

Hong Lai, Lin Lin, Mehrdad Nadji, Shenghan Lai, Edward Trapido, Lou Meng

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Among breast cancer patients p53 gene mutation is associated with a poor prognosis. Young women with breast cancer are more likely than older women to have a poor prognosis, but whether p53 gene mutation plays a role in breast cancer in young women is not clear. This study identified 199 breast cancer patients and tested the hypothesis that p53 gene mutation was associated with early onset breast cancer. Patients with p53 gene mutations were 3-times more likely to have an early onset breast cancer (age ≤ 40 years at diagnosis) than those without p53 mutations (OR=3.05, 95% CI=1.10-8.45). Patients with both missense and silent mutations were 7-times more likely to have a diagnosis of early onset breast cancer (OR=7.56, 95% CI=2.22-25.8). Patients with mutations in exon 8 of the p53 gene were 6-times more likely to be diagnosed with early onset breast cancer (OR=6.48, 95% CI=1.37-30.6). These findings suggest that p53 gene mutation may hasten the onset of female breast cancer.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalCancer Biology and Therapy
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Breast cancer
  • Early onset
  • Mutation
  • p53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

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