Mutation of the methylated tRNA₃^Lys residue A58 disrupts reverse transcription and inhibits replication of human immunodeficiency virus type 1

Agriculture & Biology

• Human immunodeficiency virus 1 100%
• reverse transcription 97%
• mutation 55%
• RNA-directed DNA polymerase 48%
• methylation 25%
• mutants 23%
• binding sites 23%
• synthesis 14%
• DNA 13%
• virion 13%
• therapeutics 10%
• chemical derivatives 10%
• cells 8%
• genome 7%

Medicine & Life Sciences

• Reverse Transcription 71%
• HIV-1 70%
• Transfer RNA 59%
• strong-stop DNA 50%
• Mutation 45%
• RNA-Directed DNA Polymerase 31%
• 1-methyladenosine 25%
• Methylation 24%
• Binding Sites 20%
• Human immunodeficiency virus 1 reverse transcriptase 18%
• Virion 12%
• Genome 9%