Mutant laboratory mice with abnormalities in pigmentation

Annotated tables

Motonobu Nakamura, Desmond J. Tobin, Beverly Richards-Smith, John P. Sundberg, Ralf Paus

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Mammalian pigment cell research has recently entered a phase of significantly increased activity due largely to the exploitation of the many mutant mouse stocks that are coming on stream. Numerous transgenic, targeted mutagenesis (so-called 'knockouts'), conditional (so-called 'gene switch') and spontaneous mutant mice develop abnormal coat color phenotypes. The number of mice that exhibit such abnormalities is increasing exponentially as genetic engineering methods become routine. Since defined abnormalities in such mutant mice provide important clues to the as yet often poorly understood functional roles of many gene products, this overview includes a corresponding, annotated table of mutant mice with pigmentation alterations. These range from early developmental defects via a large array of coat color abnormalities to a melanoma metastasis model. This overview should provide helpful pointers to investigators who are looking for mouse models to explore or to compare functional activities of genes of interest and for comparing coat color phenotypes of spontaneous or genetically engineered mouse mutants with novel ones. Secondly, this review includes a table of mouse models of specific human diseases with genetically defined pigmentation abnormalities. In summary, this annotated table should serve as a useful reference for anyone interested in the molecular controls of pigmentation.

Original languageEnglish (US)
Pages (from-to)1-33
Number of pages33
JournalJournal of Dermatological Science
Volume28
Issue number1
DOIs
StatePublished - Apr 6 2002
Externally publishedYes

Fingerprint

Pigmentation
Genes
Color
Genetic engineering
Mutagenesis
Pigments
Switches
Defects
Switch Genes
Phenotype
Genetic Engineering
Melanoma
Research Personnel
Neoplasm Metastasis
Research

Keywords

  • Coat color
  • Hair
  • Knockout
  • Malignant melanoma
  • Melanocyte
  • Pigmentation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Mutant laboratory mice with abnormalities in pigmentation : Annotated tables. / Nakamura, Motonobu; Tobin, Desmond J.; Richards-Smith, Beverly; Sundberg, John P.; Paus, Ralf.

In: Journal of Dermatological Science, Vol. 28, No. 1, 06.04.2002, p. 1-33.

Research output: Contribution to journalReview article

Nakamura, Motonobu ; Tobin, Desmond J. ; Richards-Smith, Beverly ; Sundberg, John P. ; Paus, Ralf. / Mutant laboratory mice with abnormalities in pigmentation : Annotated tables. In: Journal of Dermatological Science. 2002 ; Vol. 28, No. 1. pp. 1-33.
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