Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: Annotated tables

M. Nakamura, J. P. Sundberg, Ralf Paus

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Numerous transgenic, targeted mutagenesis (so-called knockouts), conditional (so-called "gene switch") and spontaneous mutant mice develop abnormal hair phenotypes. The number of mice that exhibit such abnormalities is increasing exponentially as genetic engineering methods become routine. Since defined abnormalities in hair follicle morphogenesis, cycling and/or structure in such mutant mice provide important clues to the as yet poorly understood functional roles of many gene products, it is useful to summarize and classify these mutant mice according to their hair phenotype. This review provides a corresponding, annotated table of mutant mice with hair abnormalities, classifying the latter into 6 categories, 1) abnormally low number of hair follicles, 2) disorders of hair morphogenesis, 3) of hair follicle cycling, 4) of hair follicle structure 5) of sebaceous gland structure, and 6) hari growth disorders as a consequence of immunological abnormalities. This annotated table should serve as a useful source of reference for anyone who is interested in the molecular controls of hair growth, for investigators who are looking for mouse models to explore or compare the functional activities of their gene of interest, and for comparing the hair phenotype of newly generated mouse mutants with existing ones.

Original languageEnglish (US)
Pages (from-to)369-390
Number of pages22
JournalExperimental Dermatology
Volume10
Issue number6
DOIs
StatePublished - Dec 6 2001
Externally publishedYes

Fingerprint

Hair Follicle
Morphogenesis
Hair
Genes
Genetic engineering
Mutagenesis
Phenotype
Switches
Switch Genes
Growth Disorders
Sebaceous Glands
Genetic Engineering
Research Personnel
Growth

Keywords

  • Hair cycle
  • Knockout
  • Sebaceous gland
  • Targeted mutant mice
  • Transgenic mouse

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure : Annotated tables. / Nakamura, M.; Sundberg, J. P.; Paus, Ralf.

In: Experimental Dermatology, Vol. 10, No. 6, 06.12.2001, p. 369-390.

Research output: Contribution to journalReview article

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