Mutagenic and epigenetic effects of DNA methylation

Mark L Gonzalgo, Peter A. Jones

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired the ability to divide more rapidly than its normal counterparts (Nowell, P.C. (1976) Science, 194, 23-28. Alterations in global levels and regional changes in the patterns of DNA methylation are among the earliest and most frequent events known to occur in human cancers (Feinberg and Vogelstein (1983) Nature, 301, 89-92; Gama-Sosa, M.A. et al. (1983) Nucleic Acids Res., 11, 6883-6894; Jones, P.A. (1986) Cancer Res., 46, 461-466. These changes in methylation may impair the proper expression and/or function of cell-cycle regulatory genes and thus confer a selective growth advantage to affected cells. Developments in the field of cancer research over the past few years have led to an increased understanding of the role DNA methylation may play in tumorigenesis. Many of these studies have investigated two major mechanisms by which DNA methylation may lead to aberrant cell cycle control: (1) through the generation of transition mutations via deamination-driven events resulting in the inactivation of tumor suppressor genes, or (2) by altering levels of gene expression through epigenetic effects at CpG islands. The mechanisms by which the normal function of growth regulatory genes may become affected by the mutagenic and epigenetic properties of DNA methylation will be discussed in the framework of recent discoveries in the field.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalMutation Research - Reviews in Mutation Research
Volume386
Issue number2
DOIs
StatePublished - Apr 1997
Externally publishedYes

Fingerprint

DNA Methylation
Epigenomics
Regulator Genes
Carcinogenesis
Growth
cdc Genes
Neoplasms
Deamination
CpG Islands
Cell Cycle Checkpoints
Tumor Suppressor Genes
Nucleic Acids
Methylation
Gene Expression
Mutation
Research

Keywords

  • DNA methylation
  • DNA methyltransferase
  • p16
  • p53
  • Transition mutation
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis

Cite this

Mutagenic and epigenetic effects of DNA methylation. / Gonzalgo, Mark L; Jones, Peter A.

In: Mutation Research - Reviews in Mutation Research, Vol. 386, No. 2, 04.1997, p. 107-118.

Research output: Contribution to journalArticle

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